I am participating in Filgotinib stage 2 clinical trials. My hope was to close complicated rectal fistula - draining seton in for 4 +years. Seton removed the day of trial start. After 3 month's, I developed an abscess in the external opening (it closed up)and had to have draining under anesthesia and seton went back in. My Gi symptoms have improved - less urgency and dria, and almost no arthritis pain. Talked with my clinical nurse in private - out of 11 people in the trial currently - 2 had full fistula closure. Everyone has improved GI symptoms.