SOURCE: Doctor Tom Borody claims faecal transplants curing incurable diseases like Crohn's"When Professor Borody offered this chance of a cure I thought: what if it works?" she said.
"They put a nasal tube down into my small intestine. I had three donors - about 950 mils - and all up it took about five hours."
She says she felt better almost immediately and over several months her condition steadily improved.
"Eleven months after having the stool transplant I had another colonoscopy to see what it looked like," she said.
"I remember I was waking up from the anaesthetic and I heard Professor Borody say if he hadn't known I'd had Crohn's he wouldn't have believed it. I was so happy."Ms Heskett's colon has been healthy for 12 years with no sign of the Crohn's infection that had kept her housebound for years."
I agree with you, Wildbill, of the potential of FMT, though this report from Borody is anecdotal. It is unfortunate that more robust random controlled studies have not been done on Crohn's patients. We need to control for disease activity, where it is located, the existing microbiota, the number of treatments, the donors' microbiota, the meds/vitamins/diet of both recipient and donor, etc., and of course the number of participants. It would also be helpful to know how long responders remain in remission. If I would just win the lottery, I'd seriously support such a study!Pretty cool guy, and they seemed to cover a lot of the best questions. He basically said anything that can damage the microbiome could cause crohn's disease. My thoughts are, so then how do we restore a damaged microbiome? a Fecal Microbiota Transplant!!! If you weren't aware yet, in my initial post of my fecal transplant thread i posted a report of a women being cured of crohn's disease with a Fecal Transplant in 2014 by Dr. Thomas J. Borody, in 2014 it was already determined she may have been cured for 12 years, and i recall another follow up a few years saying she still had no symptoms.
SOURCE: Doctor Tom Borody claims faecal transplants curing incurable diseases like Crohn's
https://www.thelancet.com/journals/lancet/article/PII0140-6736(91)90663-A/fulltextYou see what I find interesting is if you have surgery cut the disease out, and a few inches each side extra.
Then on average 2 years later the disease comes back.
So why is it coming back in the same location even when you cut it out, on an average of two years after if I recall?
"Aphthous lesions recur in the neoterminal ileum within the first few months after curative resection of the distal ileum in patients with Crohn's disease. These lesions do not originate from microscopic disease that is already present at the time of surgery."
Rutgeerts and Harper then did follow up studies on this and started filtering the fecal stream with a ultrafiltrate, 22nm, which is small enough to filter out all the bacteria and fungi. Intestinal tissue of crohn's disease patients that comes into contact with that filtered effluent, show no inflammation at all. Neither in the ileum or colon.None of the 5 patients had endoscopic lesions in the neoterminal ileum after six months of exclusion and biopsies did not show inflammatory changes characteristic of Crohn's disease. Our findings strongly support the view that recurrence of Crohn's disease in the neoterminal ileum after curative ileal resection is dependent on faecal stream.
Dalziel and Lesniowski knew bacteria or fungi were behind the disease over a century ago. Rutgeerts and Harper in the 90s had the tools to prove it beyond a shadow of a doubt.The 1985 article, that is worrying, as its almost 40 years old, and it mentions crohns has been researched extensively for a long time and yet they have not got anywhere.
It's an aspect in a subgroup of crohn's disease patience that simply leaves them more susceptible to the disease.I don't think there's much evidence for the immune malfunction theory of Crohn’s, and the way I see it the immune system is only secondary.
Qu Biologics is in phase 2 iirc with a treatment that restores innate immune system function for crohn's patients, and I'm pretty sure there's also one that targets flagellin in the works, which is what bacteria need to infilitrate deep tissue and such, if I'm remembering right.I think this is a very good theory as anecdotally my issues started after a bad case of food poisoning. Also makes sense how it can run in families, if families eat many of the same things together. However, this theory has been talked about since the 90's. I feel like if this was a solid theory, wouldn't there be appropriate treatments by now?
I wonder if anyone has tried taking L. Casei as a probiotic? The attached article demonstrates that L. Casei disrupts and displaces AIEC. Could that help calm the Crohns and initiate remission?