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What meds have failed before you starred stelara?

Getting ready for my first dose Friday. just curious as to what meds have failed for everyone? Mine are humira, methotrexate, remicade, Pentasa.
 
For me, Cimzia worked for a while and then it failed. The second time around, I had an allergic reaction to Remicade. I also had an allergic reaction to Flagyl. The same thing happened with Doxycycline. For me personally, Stelara never did anything for the Crohns Disease but everyone is different. Best to you.
 
Getting ready for my first dose Friday. just curious as to what meds have failed for everyone? Mine are humira, methotrexate, remicade, Pentasa.
I tried humira, simponi, remicade, cimzia, methotrexate, sulfasalazine. Started stelara in April 2016 and it has been the best so far.

Good luck!
 

my little penguin

Moderator
Staff member
Ronroush were you on the higher dose for Crohns 90 mg or the lower psoriasis dose 45 mg?

They have found in order to be effective for Crohns
Stelera needs to be at a much higher dose (double ) that of psoriasis patients
 

Maya142

Moderator
Staff member
For me, Cimzia worked for a while and then it failed. The second time around, I had an allergic reaction to Remicade. I also had an allergic reaction to Flagyl. The same thing happened with Doxycycline. For me personally, Stelara never did anything for the Crohns Disease but everyone is different. Best to you.
The Crohn's dose for Stelara is also given more frequently - 8 weeks vs. 12 weeks. So if it was prescribed for you as a psoriasis patient, then you may want to try it again at the IBD dose with the IV loading dose.
 
I may ask my doctor. I don't know if I am not having much success with Humira or if I have c diff. I think they might have been giving me the psoriasis level because I am not sure if it was approved for Crohns yet.
 
I have failed Remicade, Humira, Entyvio, and Cimzia. Failed many oral medications. 4 surgeries and will need another one. Start Stelara in May 2017.
 
Hi everyone. I started on the Biologics for Crohns /UC about 3 years ago with Humira. I had to drop that even though my stomach was awesome on it, I developed plaque psorasis.

Now I am on Remicade infusions but I have problems with it spiking my BP so we are stopping Remicade. I also take the Imuran.

Next drug is either going to be Stelara or Entyvio. Does anyone have a recommendation with positive results on either of these? Is there one that is more risky for other diseases?
 
Hello Jazzygirl52. Everyone responds differently to meds....I doctor at Mayo in Rochester MN. I was on Entyvio for a few months. Talk to your doctor and ask for the stats on Entyvio for Crohns patients. I think (if I remember correctly) 1 person responds to the medication out of 4.??? Not great results, but it may just work great for you. Didn't work at all for me. I am currently on Cimzia right now. Taking 1 injection every 10 days along with Imuran. Its not working. I have been on Imuran for 12 years always along with other meds & Biologics. I will start Stelara next month and continue with Imuran.
 
I tried humira, simponi, remicade, cimzia, methotrexate, sulfasalazine. Started stelara in April 2016 and it has been the best so far.

Good luck!
I was on Pentasa for years then after colon cancer, put on Humira... allergic reaction to it in year two so switched to Remicade...not as good as Humira on my digestion and it made my BP go sky high. Now choice of Entyvio or Stelara?
 
I was on Pentasa for years then after colon cancer, put on Humira... allergic reaction to it in year two so switched to Remicade...not as good as Humira on my digestion and it made my BP go sky high. Now choice of Entyvio or Stelara?
I think entyvio takes longer to work. I've read Entyvio is generally more effective for people that have disease in their colon. If I had the choice I'd choose stelara as I have disease in my ileum/small bowel.
 
I think entyvio takes longer to work. I've read Entyvio is generally more effective for people that have disease in their colon. If I had the choice I'd choose stelara as I have disease in my ileum/small bowel.
Just saw my GI and we discussed the two options of Entyvio and Stelara. He says patients have had very good luck with Entyvio...Stelara is newly prescribed for this issue in 2016 so a lot less is known. I would rather something that is specifically targeted for the GI tract vs have an impact on lots of other parts of my body.... have a few months to figure out.... Stelara is a syringe injection that I would administer... prefer Humira type pens but we will see. Any other peeps have thoughts?
 
I've been taking my Stelara now for about 10 weeks. It did take a while to work, but so far the results have been good. My current problem is c-diff. I plan to talk to GI about some good probiotics. Thanks for all the responses.
 
Failed:
Remicade and Humira. No improvements whatsoever, even with pred, 6mp, ASA, etc..

Success:
Tysabri - 3 1/2 yrs asymptomatic, but tested positive for JVC virus
And
Entyvio - 3 yrs asymptomatic, flared up after c-section, no response to med after that.. darn hormones! :(

Now: Stelara, first treatment today. We'll see
 
Hum it’s great but gave me plaque psoriasis , Remicade raise my blood pressure and wasn’t great about controlling my symptoms. Went for initial dose of stelara and got one of the serious side effects pretty soon after the infusion was almost done – my tongue and throat kind of swelled up, the sides of my head felt tight. Went immediately to the ER from the infusion and was treated with 65 mg of prednisone – went home five hours later and Feel better, next day went back to get my car got dizzy again and my throat started swelling up so back to ER
 
I'm hooked up to the IV as we speak. It's been on for about 45 minutes. No side effects yet. I'm on 30mg pred and 6mp while we transitioned from Entyvio to Stelara. Not sure if the prednisone is preventing any allergic reaction.
 
Are you switching solely because of the psoriasis? My daughter got Remicade induced psoriasis and it was awful, but we stuck with it because Remicade and Humira have the highest success rates out of al the IBD meds. Plus studies have shown that you have the best shot at responding to a biologic when you are biologic naive. My daughter lost response to Remicade and we are now trying Entyvio and having a hard time getting her to remission.

All this to say, considering the switch carefully. In our case the IBD runs the decision making process. Where is your son's psoriasis? Has he seen a dermatologist. There are topical that can help a bit. In my daughter's case she is just always a scaly itching mess but like I said her IBD is much more of a health threat when not properly controlled.
 

my little penguin

Moderator
Staff member
Ds switched to Stelara after failing remicade and later humira (5 plus years on humira )
Stelara takes 6-8 months minimum to effective

The newer biologics have only been approved for crohns for a little over 1.5 year
So the jury is still out on whether it’s more effective or as effective as anti tnf
Remicade has been out for decades and humira almost as long so the data is there to pull from

Keep in mind biologics can unmask other autoimmune diseases (not cause them )
So stopping remicade May not stop the psoarsis
 
MLP is right. In studies of people who get anti tnf induced psoriasis switching the biologic cleared up the psoriasis in only 50% of cases.

Stelara dies have the best success rate with treating psoriasis so your chances might be better but you are taking a gamble on the Crohns side.
 
Getting ready for my first dose Friday. just curious as to what meds have failed for everyone? Mine are humira, methotrexate, remicade, Pentasa.
I've been in remission with Stelara for 2 years now. I get only one injection a year of the Stelara instead of the four I should have due to the outrageous cost but the one with diet monitoring has worked. All of the meds you listed above were fails for me also. Humira worked but I had a severe reaction and broke out with blisters all over my legs every time I had the infusion.
 
I just had my infusion of Stelara on Saturday!

I was on Cimzia for 4.5 years before this, Remicade before that, and started with 6mp and Pentasa when I was first diagnosed.
 
My son developed psoriasis on remicade. Might switch to stelara. But does it keep fistulas at bay?
I had terrible fissures. I had a severe reaction to Remicade so I was put in the study to approve Stelara for Crohns and my fissures completely healed.
 
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