I have twin sons with colonic Crohn's. When they were first diagnosed, we were given the choice of Stelara, Entyvio, or Remicade/Humira. One of my sons already moved on from Stelara to Entyvio, and after 10 weeks, we aren't seeing signs that the Entyvio is really working. I've heard very mixed stories about how long it takes for Entyvio to work, but the doctor is getting impatient, and I'm getting worried. When I look at Remicade's own site, it says it works for 4/10 people but that a placebo works for 3/10. So I'm wondering, what do we do if and when none of the biologics work?