I was diagnosed with UC approx. 20 years ago. I have been on and off prednisone throughout my life, hospitalized a few times and now for the first time in 20 years I can not seem to fall into remission. I lost about 15 lbs trying to minimize the pains and trips to the bathroom. The doctor has me on 30 mg. prednisone, along with Lialda, Zegerid and now he wants me to start Humira, 160mg at first, then 80, then 40 and stay on 40mg. I guess I'm just hoping it works and the madness stops. It's hard to work, shop, cook, it's even hard to just go out with the kids. I've heard good things about Humira and hope to wean off the prednisone very soon, once I start. Which will hopefully be next week.