One of my sons (young adult) was diagnosed with Crohn's 10 months ago, so we're still early in the process of trying to find a treatment. At this point, his Crohn's is restricted to his colon - almost exclusively the lower third. However, his inflammation is severe. So far, we've tried Stelara along with Uceris and a burst of Prednisone. That didn't work, so next we're trying Entyvio. Of course I'm concerned that won't work either. I'm very worried about using immunomodulators, and I'm even worried about anti-TNFs, since there is lymphoma in the family. In any case, when I look at the statistics for how often the biologics bring on remission, they are discouraging. I'm wondering, how often is it that no effective treatment can be found?