Hi, I'm 48 and have had Crohn's disease for 20 years, after numerous medications (all of which didn't work) and 3 surgeries later, too many to mention trips to the hospital with bowel blockage I started to see a new specialist 2 years ago. I was on Prednisone (50 mg down to 5mg) and Imuran 150mg for a year but still had flare ups. Doc got PBS approval for Humira. Just had a shot this morning. It is now 8 weeks, have noticed small improvement but now that the presnisone has stopped I am extremely tired and lethargic all the time. Hoping this will improve.