kiny
Well-known member
- Joined
- Apr 28, 2011
- Messages
- 3,463
Successful Treatment of a Crohn’s Disease Patient Infected With Bacteremic Mycobacter
Haven't read this one before if anyone wants to.
http://www.ncbi.nlm.nih.gov/pubmed/17335456
The presence and subsequent disappearance of Mycobacterium paratuberculosis DNA in the blood from a Crohn’s disease patient associated with complete clinical remission.
At the age of 43, this male patient was hospitalized with
severe colitis and mouth ulcers.
At age 48, the patient was diagnosed with granulomatous colitis; however, the symptoms subsided without specific therapy until age 58, when he re-experienced the same symptoms including the detection of granulomatous colitis and was finally diagnosed with Crohn’s disease for which he received increasing doses of mesalamine, prednisone 60 mg daily, and 6-MP 100 mg daily.
At age 63, this Crohn’s disease patient refused treatment
with infliximab because of concern of possible
side effects. The result of his colonoscopy was consistent
with severe Crohn’s disease, in which the cecum and
right colon were severely involved, but skip lesions were
found in the transverse, descending, and sigmoid.
The patient consented to give two 4-mL tubes of blood for analyses
of the presence of M. paratuberculosis, the causative
agent of Johne’s disease in cattle. M. paratuberculosis DNA was present in the patient’s blood.
Consequently, the patient started treatment
consisting of split doses of clarithromycin 1,000 mg
daily, rifabutin 300–450 mg daily, and levofloxacin 500 mg
daily.
Three weeks later, his Crohn’s disease symptoms of
abdominal pains, diarrhea, and fatigue disappeared.
Haven't read this one before if anyone wants to.
http://www.ncbi.nlm.nih.gov/pubmed/17335456
The presence and subsequent disappearance of Mycobacterium paratuberculosis DNA in the blood from a Crohn’s disease patient associated with complete clinical remission.
At the age of 43, this male patient was hospitalized with
severe colitis and mouth ulcers.
At age 48, the patient was diagnosed with granulomatous colitis; however, the symptoms subsided without specific therapy until age 58, when he re-experienced the same symptoms including the detection of granulomatous colitis and was finally diagnosed with Crohn’s disease for which he received increasing doses of mesalamine, prednisone 60 mg daily, and 6-MP 100 mg daily.
At age 63, this Crohn’s disease patient refused treatment
with infliximab because of concern of possible
side effects. The result of his colonoscopy was consistent
with severe Crohn’s disease, in which the cecum and
right colon were severely involved, but skip lesions were
found in the transverse, descending, and sigmoid.
The patient consented to give two 4-mL tubes of blood for analyses
of the presence of M. paratuberculosis, the causative
agent of Johne’s disease in cattle. M. paratuberculosis DNA was present in the patient’s blood.
Consequently, the patient started treatment
consisting of split doses of clarithromycin 1,000 mg
daily, rifabutin 300–450 mg daily, and levofloxacin 500 mg
daily.
Three weeks later, his Crohn’s disease symptoms of
abdominal pains, diarrhea, and fatigue disappeared.
