Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with VALERIAN
Some medications are changed and broken down by the liver.
Valerian might decrease how quickly the liver breaks down some medications. Taking valerian along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking valerian, talk to your healthcare provider if you are taking any medications that are changed by the liver.
Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.