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thanks for the reply, I ended up taking my next day's dose at 4am and within 2 hours the pain began to subside to tolerable. Eventually by noon it was totally gone (as was the uncontrolled shaking and intense migraine-like headache). I certainly have learned a lesson... yet, I hope to one day...

First time post - woke up throughout the nite (tonight) and am experiencing horrific pain in my knees (a 10 of 10 on the pain scale). Both knees, have done nothing unusual. I don't have Crohn's (to my knowledge), but I do have both myasthenia gravis and membranous nephropathy. I take only...