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@kiny Do you think the ones that are able to manage their Crohn's purely with EEN or diet belong to the subgroup that is immune-deficient infectious-CD (IDICD)? The accidental discovery of the two subgroups using organoids is fascinating.

Propel a Cure met in a virtual meeting with Dr. Pradipta Ghosh, a clinician scientist and professor in the Department of Medicine and Cellular and Molecular Medicine at the University of California, San Diego. Also interviewed was Courtney Tindle, the Program Manager and Director at the Humanoid...

Scientists have uncovered a chemical compound that holds potential as a therapeutical for various autoimmune diseases, and they’ve used it to treat mice. https://www.oist.jp/news-center/news/2023/3/6/potential-treatment-autoimmune-diseases-revealed-new-study

OK, so you don't think that the protein needs to be broken down completely for the EN to have an advantage, right? What do you mean by "What has to be absorbed in the ileum is B12"?

My son finally finished the crate of Neocate and started on Modulen today. He loves Modulen compared with the Neocate drinks. Since he just needs to grow and gain weight, do you think Neocate is better for absorption compared with Modulen?

Crohn’s disease-associated AIEC inhibiting intestinal epithelial cell-derived exosomal let-7b expression regulates macrophage polarization to exacerbate intestinal fibrosis https://www.tandfonline.com/doi/full/10.1080/19490976.2023.2193115#.ZB7p2qN3shE.twitter

Actually they pay for the hotel stay 100% if they cannot accommodate you.

Transient Suppression of Bacterial Populations Associated with Gut Health is Critical in Success of Exclusive Enteral Nutrition for Children with Crohn’s Disease...

Have you contacted The Ronald McDonald House Charities? You can stay with them for free while seeing the doctors at CHOP. Let me know if you need details.

First patient dosed with ExoFlo™ in open-label trial https://www.businesswire.com/news/home/20230321005484/en/Direct-Biologics-Announces-Initiation-of-Phase-1-Clinical-Trial-for-Medically-Refractory-Crohn%E2%80%99s-Disease

I have not heard of any news regarding trials for this proposed treatment.

Takeda Pharmaceutical drug TAK-279 achieved the main goal of a mid-stage clinical trial in plaque psoriasis, setting the stage for Phase 3. The Japanese pharmaceutical giant sees the small molecule as complementary to its top-selling product, the blockbuster inflammatory bowel disorder drug...

We have done some testing at Mt. Sinai but I didn't look into the specifics. Is HLA B27+ something that the GI doc orders?

Thank you so much! He is only on Stelara at the moment but has had psoriasis on the bottom of his feet and a bit on his palms. The pitted nails are hanging around. I am watching those areas. Why do you think these things come in bundles like that?

Oh, boy, one more thing to worry about. My son is on Stelara. Does Stelara help with psoriatic arthritis?

My son started getting pitted nails. His dermatologist said that the psoriasis caused the pitting. Is that the same as your daughter's nail psoriasis?

It's interesting that Stelara can be prescribed on a 12-w interval in Europe

I am not able to get a copy of the newsletter so the typical screenshots will do for now. Propel really outdid itself this quarter. Take a look and subscribe on their website for the details of the upcoming kickoff meeting in Chicago! @kiny Coombes lab :)

Only if we had another kiny who understands the colon, then this forum would be complete.