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Common onset of crohn's disease is puberty. Explanation for this is uknown. An exlanation I proposed is the activity of Peyer's patches during puberty, common foodborne pathogens like salmonella and close-kin E coli tend to gain entry through m cells. But a reasonable explanation would also...

Immunologic responses to food antigens is a potential explanation for V. Kruiningen's clustering studies, the therapeutic effect of EN as an exclusion diet for crohn's diseae, and the failure of EN in UC lacking in immune response to yeasts.

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It's unlikely. Inflammation in crohn's disease is systemic, it's deep transmural inflammation visible on MRI, the inflammaiton draws in neutrophils into tisue, which is what calprotectin test are able to measure.

No, but it's not a marker for crohn's disease, elevated platelet count is seen in gastrointenstinal infections too. It's not useful as a diagnostic tool. Blood tests that are useful as diagnostic tools for crohn's disease are CRP, ASCA and Anti-OmpC. But none of them are conclusive, visual...

Well EN specifically uses glucose syrup made with hydrolysis of starch (it doesn't have anyhting to do with starches after hydrolysis). These glucose syrups are taken up very quickly. EN lacks disaccharide and starch, you don't have undigested carbohydrates left in the intestine that would fuel...

EN use decreases bacterial load and decreases the diversity of the intestinal microbiome. EN, completely lacking in fiber, goes against the idea commonly found in media outlets, that a diverse microbiome is protective against disease and that fiber rich diets should be encouraged. Bacterial...

Yes you can see architectural damage to the intestinal structure and metaplasia. In crohn's disease you can see tight pockets of granuloma. Why the biopsy is really necesarry though is to differentiate crohn from intestinal TB. While both will look very similar, you're looking for acid-fast...

Crohn's Disease onset is quite eventful and acute for many, I would say most. People often have vomiting, fevers, night sweats, aphthous ulcers in the mouth are very common, raised CRP and calprotectin. Often onset is preceded by a foodborne infection and subsequent antibiotics use. Your doctor...

Elental (popular Japanese EN) was used as EN in Chinese adults with CD. EN seems just as effective as in adults as in pediatrics. Largest drops in inflammation happened at week 4. Clinical response in 18/19 patients at week four, and all 19/19 patients at week 8. Full endoscopic remission in...

At the extreme ends of the spectrum. The lowest intake of fiber was found in Argentina. School aged children (10-12) have a daily fiber intake of 5-9 grams per day. The highest intake of fiber was found in school aged children in Denmark, 19 grams of daily fiber intake, Denmark has some Europe's...

Lack of fruits/vegetables and specifically the subsequent association with lack of fiber intake is often blamed on the increasing prevalence of crohn's disease. Especially after a study a few years ago came out suggesting lack of fiber intake was associated with later development of crohn's...

Good to hear. I don't live in the US, but I have to say it is depressing to read that some people have to wait for insurance to get medical assistance. Hopefully you get the help you need soon enough.

Fermentable fiber shouldn't be allowed on SCD, but not all fiber is fermentable. Cellulose has no no nutritional value, neither for us nor for bacteria, yet it still serves a function to bulk stool. But Fermentable fiber is a carbohydrate and energy source for microbial populations in both the...

The most important question we need an answer to. Why does inflammation return. A) due to the cessation of EN at 8 weeks B) due to the reintroduction of food at 8 weeks If A, then there is an active component in EN responsible for the decrease in inflammation, likely one that is...

-EN shows largest decrease in calprotectin at 4 weeks -EN continues to decrease calprotectin at 8 weeks but at a slower rate -Results show EN effectiveness might be dose-dependent (a similar study in Japan also suggested this) -discontinuation of EN increases calprotectin within 17 days...

Colonoscopies are a lot less invasive nowadays. The instruments are much smaller, more flexible, and they tend to do more general sedation when they know people have localized inflammation. 20 years ago colonoscopies were pretty horrible, now they are not. People complain about the prep...