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Similar study with similar conclusion. Risk of relapse is strongly associated with intake of fiber and saturated fats. Dietary intake of patients with inflammatory bowel disease: A comparison with individuals from a general population and associations with relapse Division of Human Nutrition...

The high risk of relapse after reintroduction of fiber and cereals can simply be mitigated by employing low residue diets. They need to do many more of these studies, the sample size needs to be bigger. The association with the reintroduction of fiber/cereals and return of inflammation is...

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In the 1980s, Belgian GI and surgeon Rutgeerts said it aptly: "To cut is not to cure", meaning a surgical intervention generally does not keep the disease at bay. The Crohn's "Rutgeerts score", which is still used today, is named after him, which predicts crohn's recurrence in patients. If you...

Another thing, probiotics are not "harmless". Infections following use of over-the-counter probiotics are well documented and more common than people realise, in both children and adults. When people with crohn's disease come onto this forum seeking advice regarding colonoscopy results...

Koch's postulates exist to avoid a dangerous thought process, to avoid creating situations where patients would end up being guinea pigs as a result of bad conclusions. Dysbiosis is a common feature of any inflammatory reaction to antigen, certain bacteria bloom under inflammatory conditions...

Billions of have been spent on microbiome research, probiotics, prebiotic and fecal tranplant research. It has not helped a single person with crohn's disease. People with crohn's disease are not guinea pigs, there's no room for "trial and error". These are errors and experiments people with...

EN, highly processed and completely lacking in fiber, leads to 85%+ remission rates, often including fistula closure. Fiber-rich "natural" plant diets do not lead to remission. The "good bugs" theory failed. Probiotics don't work. Prebiotics don't work. Fecal transplants lead to disastrous...

MRI and ultrasound are cross-sectional, they can show increased wall thickness indicating inflammation. You compare wall thickness on the slide with other parts of the intestine, and you can literally measure it, below 3mm is normal, above 4mm indicates disease activity. But only colonoscopies...

It's very possible that the innate immunodeficiency stage presented in crohn's dsiease is actually quite minor. We don't tend to have major issues clearing non-GI infections. But when the epithelial barrier is compromised after chronic inflammation due to innate immunodeficiencies, large...

Macrophages are the immune cells of the innate immune system. They're very important in crohn's disease, they are the primary defense when microbes manage to get past our first defense, the physical intestinal barrier made up of the mucus layer and epithelial cells. Pathogens will encounter...

Crohn's disease involves a defective innate immune response. You can see this from the susceptibility loci. NOD2 and ATG16L1 mutations hinders competent authophagy required for clearance of intracellular pathogens. ATG16L1, or Autophagy related 16 like 1. Most people know autophagy can be...

Those studies where multiple macrophage penetrating antibiotics are successfully used to induce remission for months in crohn's disease patients, the so-called antibiotic cocktails, likely are effective. But you're exposing patients to an aggressive course of antibiotics, you require 3 or 4...

Rifaximin is only advised for noninvasive E coli like travellers diarrhoea. Rifaximin is non-systemic, unable to penetrate activated tissue macrophages in crohn's disease, so I don't understand the intention of that study. In crohn's disease you have chronically activated lamina propria...

Not sure, but discussions regaring crohn's disease clearly went completely off track after the 1970s. During the 90s and 2000s, crohn's disease was referred to by GI as an "overreactive immune system" without any proof. GI were adamant that dietary manipulation was useless. Pathogens didn't...

"Pathobionts" is an awful recently invented term. Pathobionts are just pathogens, every pathogen is conditionally invasive. The term if often used to shield microbiome research when it turns out the microbiome is not as harmless as initially assumed, and includes a lot of unknown and invasive...