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Specific gut pathobionts escape antibody coating and are enriched during flares in patients with severe Crohn’s disease 2024 Feb 23 Department of Biotechnology and Biomedicine, Technical University of Denmark Objective Patients with Crohn’s disease (CD) exhibit great heterogeneity in...

I would like to know what happened with GI and research between the 70s and today. TPN is from 1960 when Stanley Dudrick introduced it in clinical practice. In the 70s doctors realized TPN and EN induced remission in crohn's disease patients. The data that dietary intervention through TPN and...

1973-1977 discussion on use of Intravenous alimention (bowel rest) in crohn's disease for nutritional support. Subsequent realisation it induces remission in patients with Crohn's disease, but not UC. Crohn's Disease was referred to as Regional Enteritis back then. DR. FRANCIS C. NANCE (New...

For what it's worth, protein digestion and absorption is likely highly efficient when consuming EN. Of the 61 liquid formulas Michael Logan et al analysed, almost all of them contained either whey or casein, and of those generally used to treat crohn's disease, all of them did. I have no data on...

Amount and fate of egg protein escaping assimilation in the small intestine of humans 1999 P Evenepoel, D Claus, B Geypens, M Hiele, K Geboes, P Rutgeerts, Y Ghoos University Leuven, Belgium The availability of stable isotope-labeled protein allowed us to determine the amount and fate of...

The CD fecal stream high in bacterial products is associated with mucin-degradation, but there is no association with relative abundance of bacteria after sequencing tests.

Data behind CDED is weak, certainly not good enough to support using this diet outside of studies. I have voiced my scecticism over CDED claims several times.

In vitro mucin degradation and paracellular permeability by fecal water from Crohn's disease patients 2024 Mar 12 ahead of print Department of Gastroenterology/Hepatology, Maastricht University, The Netherlands Aim: This study aimed to examine the impact of fecal water (FW) of active and...

Maybe showing this video helps to get over any hesitations. I can only speak for Europe, but I have been using EN for years and bring it along with me everywhere, people inquiring about it has been very rare, since it just looks like a protein shake to people.

139 patients Moderate to severe crohn's disease. No difference from placebo. 1129×1168 346,3 kB 280 subjects. Moderate to severe crohn's disease. Efficacy not significantly different from placebo. 78 patients. Moderate to severe crohn's disease. No difference from placebo.

Michael Logan et al. showed at least 61 different EN formulas have shown clinical efficacy in crohn's disease. When talking to the authors, they were convinced remission can be achieved by many different formulas. Analysis of 61 exclusive enteral nutrition formulas used in the management of...

NOD2 mutations impact both bacterial, but also fungal clearance. Chitin is a component of the fungal cell wall, and recognition of this component seems to be NOD2-dependent. Around 50% of CD patients in the West have at least 1 such NOD2 mutation. The encouraging aspect is that far more people...

The small lesions in early onset crohn's disease look a lot like the aphthous ulcers seen in the mouths of chrohn's disease patients. They heal in the mouth, but develop into deeper transmural inflammation in the intestine. That might just be because of the much higher bacterial load in the...

It's posted above. https://crohnsforum.com/threads/molecular-and-phenotypic-characterization-of-escherichia-coli-associated-with-granulomatous-colitis-of-boxer-dogs.85825/page-2#post-1053657 "The enemy is in the fecal stream" wrote Balfour Sartor. IV feeding is highly effective in inducing...

Note that bacteria/fungi are a prerequisite to maintain crohn's disease, as inflammation would not exist in a sterile environment. This also puts into question the wisdom of some GI who performed fecal transplants to treat crohn's disease, and were somehow shocked it exacerbated inflammation...

As this study rightly points out, the fecal stream drives inflammation. However, this is one of several studies showing there was no difference between the microbiota of inflamed and non-inflamed tissue. This suggests dysbiosis is a consequence of inflammation, not a cause. If the...

Antioxidants are able to mitigate some of the tissue damage from the oxidative response of macrophages. Interestingly, people with crohn's disease tend to be deficient in some of of those antioxidants. Inflammation in the ileum not only damages intestinal tissue, it leads to malabsorption...

That the fecal stream maintains inflammation is very well documented, Harper, Rutgeerts, etc. All studies from the 80s and 90s, but still some of the best clues we have. We also know IV feeding leads to significant drops in inflammation.

The fact oral ulcers always seem to resolve on their own in people with crohn's disease, is another reason I do not believe an immune response against commensals or "the microbiome" is actually persistent. I do not see this as loss-of-tolerance at all. I think it is simply lumen content entering...

The intersting thing about the oral aphthous uclers in crohn's disease, is that it comes and goes in patients. Mucosal tolerance is shared in the body, so are some bacteria in the intestine and oral cavity, there is a difference but also some overlap. When lumen content high in bacterial load...