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FYI: Random find. Old Mike http://www.ncbi.nlm.nih.gov/pubmed/21703899

Xiaofa: Thank You. As you can see pubmed/medline does not have everything we might be looking for,you must use google with some specific search terms. Here is the path I went down yesterday,which I copy and paste from another forum I frequent. I went down the path of antibiotics and gut...

Xiaofa:You might be interested in this old paper,if you have not seen it in the past. These findings indicate that inactivation of pancreas tryptic activity is mainly carried out by the intestinal microbial flora. Old Mike http://www.microbecolhealthdis.net/index.php/mehd/article/viewFile/7395/8728

Xiaofa: Part of the problem is the not invented here syndrome with American doctors. What really baffles me is that since say around the 1930's some of the best medical minds have been working on IBD,with no solution. There last chance perhaps for a cause is emerging countries like China,I...

FYI: Old Mike http://www.ncbi.nlm.nih.gov/pubmed/24494172

Xiaofa: I ran across that study on my searching on China. I believe the research doc's are missing a big opportunity to solve the cause of IBD if they do not concentrate efforts on countries such as China with emerging/increasing IBD incidence. Old Mike

Thanks Xiaofa: We have known about the sugar connection for many years. What I have never seen, or no one will admit is that untreated water is protective for UC. Perhaps the connection is only possible in China or few other places. In the USA and England the connection is buried in time. We...

Now this is interesting,in China they say tap water is protective for UC. The first time I have ever seen that one. Meaning it is untreated, as opposed to boiled,and that none pathogenic bacteria in the tap water is having an immune modulating effect. Chlorination in the USA started around 1908...

I have been trying to do this for years,but lots of multiple factors that perhaps change with time. Early on 1890's, early 1900's-1920 ish. MAP new in 1895,new viruse,aluminum in baking powder,artifical lights,office work/indoor,cities,central heating,shift work,chlorination,lead...

Xiaofa: I don't know whether you are right or wrong on the artificial sweeteners,I never ate any,except in toothpaste. I have now eliminated saccharin from my toothpaste. But we do know at least in UC there is excess protease in the colon,this does cause a problem. We also know from very small...

This work is a bit different than what we normally see. Interesting they found no MAP. Old Mike http://www.ncbi.nlm.nih.gov/pubmed/24429583

Can anyone get the full paper on this so we can figure out exactly what they are saying here,this one is a few days old. Old Mike Curr Opin Gastroenterol. 2014 Jan 16. [Epub ahead of print] Proteases and small intestinal barrier function in health and disease. Giuffrida P, Biancheri P...

Xiaofa: Thank you for the paper on trypsin output from the pancreas. I may start to eat more starch and less meat. Of course we have macrophage protease,and other proteases to worry about also. Old Mike

Thank you Xiaofa: The first paper I posted talks about increased bacterial protease from dysbiotic bacteria even in the abstract. http://www.wjgnet.com/1007-9327/pdf/v19/i43/7531.pdf Xiaofa said: "I do not say bacterial proteases are completely innocent in IBD. However, the reduced gut...

Macfarlane also indicates that. Comparative studies with faeces from a person who did not have a pancreas suggested that a substantial proportion of the proteolytic activity in normal faeces was of bacterial origin. If we have dysbiotic bacteria which produce excess protease then perhaps a...

Here is a new comprehensive review on protease and IBD. Seemed slow to load. Old Mike http://www.wjgnet.com/1007-9327/pdf/v19/i43/7531.pdf

They had butyrate enemas for UC, but they do not work that great,possibly just for clinical trials,cant remember. Another way to get butyrate is resistant starch,which is fermented in the colon. Green banana, unmodified potato starch, beans, retrograde starch, potatoes and rice that have been...

Here are a few links from my old melatonin thread on healingwell. Old Mike http://www.nytimes.com/2011/07/05/health/05light.html?pagewanted=all&_r=0 melatonin and UC http://www.livar.net/uploadedfiles/article/melatoninandulcerativecolitis.pdf http://www.ncbi.nlm.nih.gov/pubmed/21893693...

Xiaofa,here is a quick look at some of the questions you brought up on beef imports and also MAP antigen,seems that timelines are suggestive. Saudi beef imports chart,big increase since about 2000. Old Mike...

MAP is also found in ground beef, in the usa ground meat is usually made from culled cows,at least the bulk kind. Anyway Japan imports a lot of meat for hamburger from Australia and New Zealand, could this be the reason crohns increased while domestic herds in Japan had low MAP. MAP was a new...