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I searched this one does not seem to be in the thread. Induction of Intestinal Inflammation in Mouse by Activation of Proteinase-Activated Receptor-2 From 2002 Old Mike https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850779/ What we have going on here is PAR-2 activation by trypsin and mast cell...

Seems that AIEC might also be implicated in UC. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133521/ Inhibitors of adhesion so far that we can get are Danactive with a particular strain of L casei DN-114 001 , but cant seem to find Danactive at any store sites anymore, did they stop selling...

Just to add a bit more,cellulose might be a bad actor. Looks like all fiber is not created equal, and we know there is a lot of CMC used as a food additive. http://www.jimmunol.org/content/196/1_Supplement/67.11 AIEC generates its own cellulose. http://iai.asm.org/content/83/10/4068.full now...

This may tie many things together, quite interesting and exciting. Immune Recognition of Heat Shock Proteins Provides a Molecular Basis for the “Hygiene Hypothesis” Linking High Prevalence of Immune Disorders to Lack of Cell Stress Eliciting Events hsp70 is not just about the rescue of NOD2...

Thought I would chime in on this old thread. The govt admitted a few years back that there were using agent orange in Korea on the DMZ, well I was there in 1971 in/on the DMZ during the time period covered by the govt. Yet still today IBD is not a disease associated with agent orange exposure...

Lady: Cinnamon oil is kind of strong, try eating cinnamon first. Ceylon is supposed to be safer in large amounts since in contains little to no coumarin, as compared to Cassia the regular store brands. Coumarin may cause liver damage. http://www.medicalnewstoday.com/articles/260430.php But...

Dan: Sounds too hot check your temp with an oral thermometer probably don't want to go over 102 or so. Cant you get the sauna temp lower. You may need to do more than once a day, so hydrate first. My experiment just showed that you can get to 102 F in 20 minutes with say 115 F water. 102 F...

Just did a semi controlled experiment. Bathtub hot water, but could have stood hotter, did not measure temp, my bad. Tub too short so knees and of course head was exposed. Measured oral temp with good old mercury thermometer, yes still have one. Started 98.6 F - End 101.8 F after 20 minutes...

Just to add a bit more on hyperthermia. Fever induces endogenous TNF inhibitors. Sometimes I wonder about the multi billion dollar biologic anti-TNF industry, if there is something they are not telling us. Cant find much on this after 1991, of course using inhibitor in search terms leads to...

Dan: The problem with ozone is that it kills everything, which may cause worse problems, sounds dangerous. Believe me long ago ate a lot of hydrogen peroxide and iodine, no help. Just targeting the gut with diathermy, don't know may need systemic activation of HSP70,back in the day they also...

Can't seem to edit my own post for some reason,so have to add a new one. Just wanted to make sure that you know, that heat induces heat shock proteins. Otherwise know as hyperthermia. Here are some mouse studies. Don't believe your gi is going to tell you to get into a hot tub or sauna. On...

For those interested have found the whole HSP70/NOD2 paper. Seems to me that if you can epigenetically manipulate NOD2 defects then you might see some improvement in crohn's symptoms. Oregano oil/pectin/glutamine/saffron might be an approach,take your pick. By the way tried the SCD diet 3...

Hey Dan: I have tried most supplements that you might think of that were supposed to help UC, still have UC. Anyway if glutamine is working for you, keep it up,is was in the article I posted to up regulate HSP70. One thing I have learned is that as soon as I might detect an adverse even...

Since this is a crohn's forum will go down this path and another a bit more. Old Mike A big IBD fungus study, to go with the other info. You might also want to look into HSP70 being induced by oregano oil which contains lots of carvacrol, hsp70 then down regulates some inflammatory markers and...

Hey Dan: I post most of the things I find over on the healingwell ulcerative colitis board. If I find interesting crohn's info I will also post it here. Some are helped with combination oils such as oregano,clove,cinnamon,thyme, fresh garlic. I am pretty sure you know me from another board...

Here is a Chinese human study on cinnamon oil which will kill the particular candida species, mentioned in the above paper. Old Mike http://www.journaltcm.com/modules/Journal/contents/stories/121/4.pdf

FYI. Hot off the press. Of course a question what came first the biofilm or the disease. Old Mike http://medicalxpress.com/news/2016-09-team-fungus-humans-key-factor.html

I see this thread is still going. I posted this info back in 2013 or so. Seems overlooked by the GI community. Old Mike yes only 2 people but it worked https://www.jstage.jst.go.jp/article/internalmedicine1992/32/4/32_4_350/_pdf BBI http://www.ncbi.nlm.nih.gov/pubmed/17551835 potato juice...

Here is another new one, when I was a kid back in the 50's they mostly used penicillins and in the form of shots. So since then they have pretty much switched from narrow spectrum to wide spectrum antibiotics. But even this does not quite explain the increase in IBD from say around 1920 ish...

Well besides possible poor absorption, cachexia probably going on. http://www.ncbi.nlm.nih.gov/pubmed/16087987 One possibility is glycine/gelatin,bone broth, but the easiest way is glycine powder, you can get it on amazon or health food store. Contrary to general believe that glycine is none...