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bump for becky. a sage before her time

https://rmdopen.bmj.com/content/7/3/e001755 Intestinal microbiota changes induced by TNF-inhibitors in IBD-related spondyloarthritis Conclusions Our findings are consistent with the hypothesis that TNFi therapy tends to restore the intestinal eubiosis.

kitchen experiments? lol, they are backed by thousands of hours of personal research and ibd symptoms and inflammatory arthritis disappearing forever. my target from day one on this forum has been gut dysbiosis. now i've discovered that the drugs you and other members recommend help ibd...

researchers conclude that plant diet (prebiotics) helps dysbiosis drug outcomes https://www.gastrojournal.org/article/S0016-5085(20)30231-6/pdf How to Optimize Effects of Infliximab in Inflammatory Bowel Disease: Incorporation of a Plant-Based Diet We recognize that a westernized diet is a...

finding that the popular ibd drugs work by modifying dysbiotic microbiomes. changed the title of this thread to reflect that. this is great news! we can possibly use the drugs to get a jump start on building a legitimate healthy microbiome. when the microbiome is fixed, dump the drugs...

https://journals.asm.org/doi/10.1128/msystems.00188-17 We found that imbalanced microbial diversity and reduced Clostridiales abundance in CD patients were restored in patients who responded to infliximab treatment. Moreover, the use of the gut microbiota, alone or together with calprotectin...

these guys find the same - inliximab modifies the dysbiotic microbiome towards a healthier mix of bugs. also claim to be able to predict infliximab outcomes based on the patient's microbiome i should've done this research before today. it ties us all together - dysbisosis as the cause and...

small study shows bifid bacteria determine effectiveness of infliximab. this supports the body of work that i've posted at this site. some (all?) of the leading drugs for crohns do exactly what i've been advocating for - targeting/modifying gut dysbiosis. it's telling that infliximab doesnt...

butyrate again, this time for biofilms https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1151552/full In addition, we propose that the abrupt decline in probiotics, particularly those that produce butyrate, modifies the pattern of bacterial growth from dispersed to...

https://www.sciencedirect.com/science/article/abs/pii/S0003996919300044 Effect of Polyphenol-Rich Cranberry Extracts on Cariogenic Biofilm Properties and Microbial Composition of Polymicrobial Biofilms

good read on dissolving biofilms https://www.clinicaleducation.org/resources/reviews/dissolve-biofilms-with-fibrinolytic-enzymes-autism-support/ Dissolve Biofilms With Fibrinolytic Enzymes treating chronic bacterial infections and biofilms that involves some new insights and relies in part on...

thought this was interesting -- infliximab (remicade and inflectra) work by changing the microbiome. so does methotrexate. this is why it takes so long to work - as it's the same time frame as probiotics/prebiotics to work. takes time to change the profile of a microbiome that is a trillion...

https://www.mdpi.com/2673-5601/2/4/42 25 November 2022 Regardless of genetic background, the number of patients with IBD has increased. This phenomenon suggests that the rapid increase in the incidence of IBD is parallel to changes in lifestyle, such as diet, breastfeeding, and antibiotic use...

possible pathogen https://pubmed.ncbi.nlm.nih.gov/36968108/ Currently, gastrointestinal infection has been proposed as one initiating factor of CD. Yersinia enterocolitica, a zoonotic pathogen that exists widely in nature, is one of the most common bacteria causing acute infectious...

strong evidence they say. dont see that very often on pubmed https://pubmed.ncbi.nlm.nih.gov/38585636/ An advanced search considered clinical studies on probiotic for IBD from inception to 2023 in PubMed, Embase, Cochrane Library, and Web of Science. In the treatment of UC with probiotics...

here's how it goes down -- leaky gut allows toxics into the blood. body sees those molecules in the blood and surrounds them. then it removes them from the blood, stashing them wherever it decides -- if it stashes in joints (inflammatory arthritis) or if stashed in muscles (fibromyalgia)...

might have to up the dose to tamp it down. then start tapering again. are the joints warm to the touch and/or red?

this post links to the one above --- researchers suggested this cocktail to be used with the anti-tnf https://www.nature.com/articles/s41598-017-11734-8 Butyrate-producing bacteria supplemented in vitro to Crohn’s disease patient microbiota increased butyrate production and enhanced...

informative study, just posted a clip of it. the first signs of relapse include the loss of the main scfa/butyrate producers. later in the relapse process the minor scfa/butyrate producers can go down too, worsening symptoms. in the conclusion the researchers speculate that a probiotic...

prednisone for the joints/pain. doc is right - stay away from nsaid. you have a gut issue and nsaid makes it worse. until you get the prednisone try not to eat much - and keep it light/clean if you do eat. there's often a link between flaring joint pain and eating. ice can help the pain...