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There are several studies published recently that may be of some interest. One study showed that the incidence of IBD in the children in Shanghai, China increased 12-folds from 2001-2010 (Wang XQ, et al. Inflammatory bowel disease in Chinese children: a multicenter analysis over a decade from...

A scientist at a scientific institution contacted me to discuss my hypothesis on the possible link between sucralose and IBD, and also informed me a blog at Evidence Based IBD (http://evidencebasedibd.blogspot.com/2013/03/artificial-sweeteners-and.html ) with comments and critiques on the...

Thank Grungel for sharing the thoughts and experience. To my knowledge, multiple studies back to 1980s found increased intake of refined sugar in patients with Crohn’s disease...

Thanks Old Mike for checking out and sharing this interesting article. Xiaofa

Thanks Old Mike for checking out and sharing these articles. Multiple studies showed that HO-1 is induced at the site of inflammation or injury, with beneficial effects to the body. I am just a researcher but not a doctor. I just suggest to be prudent when trying something out, especially for...

Not yet. I indeed feel we have some big problem in the current funding system. For instance, I believe I have more thorough and deep thinking on IBD than many IBD professionals and that is how I can construct this unified hypothesis on the etiology of IBD. However, due to the lack of direct...

I found a thread in this forum started by D Bergy entitled “Most medical research false?”. I think it would be not accurate to say most of medical research false. However, in my opinion, there are some fundamental problems in medical research that is far beyond just the bias caused by the...

This report was published two decades ago. Apparently, it was not further pursued but rather forgotten. This just represented the fate of those that is out of the mainstream of thoughts and fantasy. No matter how promising it is, nobody cares. Soon it will be destined to oblivion.

Thanks Old Mike for checking out and sharing the info. Hope new clinical trials will be conducted and new drugs (treatments) may develop that may get rid of the root of the disease and lead to a real cure of IBD without the need of lifelong medication.

Thanks Old Mike for sharing the article. The results are amazing but not surprising. It would be just what may (should) happen according to the hypothesis discussed here. Unfortunately, it is just case report. It would be worthwhile to conduct some randomized, double-blind, placebo-controlled...

Thanks Old Mike for checking out and sharing the info. I added a little more discussion and info in the previous post (#130). Although IBD may be caused by many factors, a true contribution of each factor may depends on the extent of consumption, the strength of their toxic effects on the...

I know soy products like tofu and soybean sprouts are among the common dishes in East Asian. Do not know if this may have contributed to the relatively low incidence of IBD even in the developed countries or regions like Japan, Singapore and Hong Kong. But I feel IBD seems more likely to be...

Old Mike: thank you for the great effort you take and sharing the info. Yes, there are many studies and publications on BBI before. By the end of the paper published in 2008 regarding the clinical trial of BBIC on ulcerative colitis (Lichtenstein GR, et al. Bowman-Birk inhibitor concentrate...

Thanks Old Mike for checking out and sharing the lots of information. Without a more vigorous test, even myself do not know how much this hypothesis would be correct. Hope it would not be true. Otherwise we would have already lost more than a decade for a more effective prevention and...

Hi, Old Mike: This is really a very interesting article. Thank you so much for sharing it. This study suggests that, under normal condition, the small intestine has high protease activity but low glycosidase activity, while the large intestine has high glycosidase activity but low protease...

Again, the core of my hypothesis is the impaired inactivation of digestive proteases rather than the activity of beta-glucuronidase. I do not find evidence suggesting vegetables and fruits may have caused such a problem. In fact, I suspect that human IBD would be more like the IBD in pet dogs...

Thanks Old Mike for sharing the thoughts and info. The core of my hypothesis is that the primary cause of IBD is the over digestion of gut barrier by the poorly inactivated proteases (most may from the pancreas, but some may be from the bacteria) due to the inhibition of gut bacteria by dietary...

Some people wondered why the inflammation of ulcerative colitis (UC) is limited in the mucosa, while in Crohn’s disease (CD) the inflammation is transmural that can be seen in all layers of the gut. This would be a very basic and yet important question but hardly any textbooks or articles on IBD...

Thank kiny for making me learn more and think more. Frankly, by nature I do not like to argue with people, but would like to exchange information and opinions to make our thoughts more clear. Yes, there are many differences between human and cow. However, the long lasting MAP controversy seems...

Thanks kiny for sharing the thoughts. I admired the great efforts you and many other patients in this forum took, trying so hard to understand the diseases. The body is very complex. Apparently, it is not easy to read through the many research papers with the many jargons. Frankly, my...