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However, according to the more recent publication by Dr. Saleh A. Naser et al, MAP seems more linked to ulcerative colitis (UC) rather than Crohn’s disease (CD). Using the golden procedure they developed, Dr. Naser’s lab in University of Central Florida (UCF) found viable MAP in the blood of...

In my paper (Fig. 4, http://www.ncbi.nlm.nih.gov/pubmed/22553395) and previous posts (#109 and #114 in this thread) I showed some evidence regarding the remarkable increases of IBD shortly after the approval of sucralose in western countries like Canada, the US, Australia, New Zealand, Norway...

Thanks wildbill for the post. This is just the article I first saw in early last year that led me to suspect the possible link between sucralose and IBD (as described in the previous post #28 in this thread).

Just found this study presented at the 2007 Digestive Disease Week (DDW) by Dr. Steven B. Ingle and colleagues at Mayo Clinic, entitled “Increasing Incidence and Prevalence of Inflammatory Bowel Disease in Olmsted County, Minnesota, During 2001-2004” (Gastroenterology 132 (4 suppl): A19-A20...

Thanks for sharing these interesting articles.

Thanks kiny and Mark for the kind congrats. As for NOD2, many studies have well documented that NOD2 has been the risk gene having the strongest association with Crohn’s disease. Despite that, as pointed by kiny, NOD2 not only failed to show an association with CD in Asian as demonstrated in...

I was informed by the Journal of Crohn’s and Colitis that the manuscript I submitted entitled "Have genome-wide association studies or knockout mice more reflected the true nature of inflammatory bowel disease?", a topic that was discussed in the previous post (#98), has been accepted for...

Thanks Old Mike for sharing the thoughts. Indeed, million things may be changed along with the modernization; each of them may be correlated somehow with the changes in IBD at certain time point and thus presented as a possible connection. So what should we do? Give up or continue? Can we still...

I think we would have to face the fact that IBD emerged and dramatically increased in modern society along with the improved hygiene. However, the “hygiene hypothesis” and I have a totally different explanation for this increase. The “hygiene hypothesis” proposed that the increases in the...

Thanks wildbill_52280 for sharing the thoughts. I think everybody understand and appreciate the great achievements in genetic research since last century. Actually, I had communicated with Dr. James D. Watson, the co-discoverer of the double helix structure of DNA more than two decades ago when...

Thanks wildbill_52280 for sharing those interesting articles and thanks kiny for sharing the thoughts. I have totally the same opinion as kiny described in the post (#100). As for research on the microbiome, I also felt the assessment of each gut bacteria by means like genetic analysis seemed...

Thanks all for the response and support. I felt there are some big problems in IBD research, likely even beyond. The great efforts are not dedicated to solve the problem based on dynamic reasoning, but rather great resource has been spent to fulfill some miraculous fantasy generated by those...

I started a discussion last month at several IBD-related LinkedIn groups including the European Crohn's and Colitis Organisation ECCO, CCFA (Crohn's & Colitis Foundation of America), IBD - Crohn's disease & Ulcerative Colitis – CCF, and IBD Research Foundation, entitled “We should put a little...

Thanks kiny for sharing this interesting article.

Thanks wildbill_52280 for sharing the analysis and thoughts regarding this paper ((http://www.nature.com/labinvest/journal/v92/n3/full/labinvest2011156a.html). Actually, this paper you provided has made me read more on adherent and invasive Escherichia coli (AIEC) and related research in recent...

Thanks wildbill_52280, Old Mike and PlutoCronie for sharing the info. I read through the article provided by wildbill_52280 (http://www.nature.com/labinvest/journal/v92/n3/full/labinvest2011156a.html). I found it a very interesting study with fascinating conclusions. However, I was confused...

Thanks wildbill_52280 for the interest in my opinion. Frankly, I have not read much on the possible link between Toxoplasma gondii and IBD. According to Wikipedia (http://en.wikipedia.org/wiki/Toxoplasma_gondii), “the rates of positive sero-prevalence in women at child-bearing age between 1990...

Thanks wildbill_52280 and PlutoCronie for sharing the experience and info, and thanks kiny for the kind praise. I also appreciate the many people having interest in this hypothesis and shared their opinion. As I described in earlier post, I found the possible link between saccharin and IBD just...

Thanks wildbill_52280, PlutoCronie and kiny for the comments. Following is my personal thoughts and opinion. As for why the inflammation in IBD became persistent rather than resolved quickly as a wound on a skin, there are several reasons I can think of: 1) the inflammation of the gut would...

Thanks Old Mike for the comments. Yes, there are numerous possibilities. Hope one day people can still figure out the fundamental cause(s) and mechanism(s) of IBD.