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Several years past since the last post. More studies emerge. I have also had more publications that can be found at: https://pubmed.ncbi.nlm.nih.gov/?term=Xiaofa+Qin Recently, I also put a video on YouTube with my simple explanation as how changes of gut microbiota in modern society may...

It seems you still disparate over the papers I wrote regarding the inverse relationship between milk consumption and the risk of IBD negated the causative role of MAP in CD (Qin X. Increased Milk Consumption but Decreased Risk of Crohn's Disease (CD): Critical Evidence Negated Causative Role of...

Hi, irishgal – Thank you for the explanation. Wish you keep on this wonderful good health all the time. Admire your great enthusiasm for helping others. Hope we may find out the root cause and mechanism of this dreadful disease sooner, no matter what it would be, and provide not only a cure but...

I think we all share the same goal of ending the suffering of disease imposed on human being. I know even some minor personal experiences may greatly affect the belief of an individual on something. However, this kind of belief is also the most unreliable. You have mentioned in other post that...

Thanks for sharing these info. From these materials we can learn that more than 90% of the serotonin in the body is located in gut tissue and mainly produced by the EC cells in the mucosa, with the materials generated within the body rather than exogenous sources like diet. Gut bacteria may...

Thanks irishgal, Zim, InstantCoffee for sharing the thoughts and info. More and more studies showed changes in gut bacteria along with changes in the hygiene condition, or use of antibiotics or some diets may have played critical role in IBD and multiple other diseases. To my knowledge, I know...

irishgal: Thank you for sharing your thoughts and statements. I understand and agree for many of what you said, but not for all, especially in some key issues you are addressing. For instance: I do not think what you suggested is the standard way of disclosure of confliction. I have...

Here is a link with the introduction to vaccine: https://en.wikipedia.org/wiki/Vaccine As stated, "a vaccine is a biological preparation that provides active acquired immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing micro-organism and is...

Thanks for sharing your thoughts. Due to the damage of gut barrier in IBD patients, to my perception, a reduction in gut bacteria and thus the luminal commensal bacterial toxicants by the antibiotics should have some beneficial effect even in the absence of MAP. I wonder the impaired...

Depend on the extent of damage of the gut tissue and stage of the disease, it may not be easy or possible to reverse the course of the disease by just removing the primary causative agents. In my opinion, if the damage of the gut tissue is still reversible (such as no severe fibrosis that...

An interesting explanation. Could you give an example showing a reverse relationship between exposure to a pathogen and prevalence of the disease caused by the same pathogen?

Thanks for sharing your thoughts. I would be glad if any people would like to share their thoughts on this with different opinions, including insightful discussions over scientific journals with those firm proponents of prominent scientific and professional backgrounds. Debate may help to...

In my opinion, there should be fervent discussions and debates among the different hypotheses and opinions regarding the possible cause and mechanism of IBD. I believe the cure and prevention of IBD largely depends on finding out the root cause and mechanism of disease, which might turn out to...

I believe the reverse relationship between milk consumption and the risk of inflammatory bowel disease (IBD) as revealed in the recently published European study (Opstelten JL, Leenders M, Dik VK, et al. Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease: Results From a...

Regarding the decreased risk of inflammatory bowel disease (IBD) with increased intake of milk that was published recently on Inflammatory Bowel Disease (Opstelten JL, Leenders M, Dik VK, et al. Dairy Products, Dietary Calcium, and Risk of Inflammatory Bowel Disease: Results From a European...

Immunol Lett. 2015 Mar 28. pii: S0165-2478(15)00048-6. doi: 10.1016/j.imlet.2015.03.007. PMID:25827759 Can inflammatory bowel disease really be solved by the multiple -omics and meta-omics analyses? Xiaofa Qin, M.D., Ph.D Founder/President GI Biopharma Inc New Jersey USA I read with great...

Microb Cell Fact. 2015 Feb 26;14(1):26. doi: 10.1186/s12934-015-0198-4. Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci. Bermúdez-Humarán LG1,2, Motta JP3,4,5,6, Aubry C7,8, Kharrat P9,10...

A large scale multi-countries prospective epidemiological study just comes out (Chan SS, et al. Carbohydrate Intake in the Etiology of Crohn's Disease and Ulcerative Colitis. Inflamm Bowel Dis. 2014 Sep 26. [Epub ahead of print] ), showing no association between the intakes of carbohydrates...

I am not implying some people have figured out the cause of the disease and held it out. Rather I am suggesting the need to put more efforts to find out the cause of the disease. Thanks for sharing the thoughts. As a chronic disease without a cure, I do not think workload of GI may result in...

Yes, the recent striking increase of IBD in many countries over the world seems unlikely to be explained by sunshine/vitamin D. Interestingly, there are multiple recent reports on decrease in the incidence of IBD including both Crohn’s disease and ulcerative colitis in Canada (Leddin D, et al...