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How are you getting access to this stuff? Are you enrolled in a clinical trial?

Since I have no personal experience with inflamed post-surgical sites, I would just be guessing. So I would agree with your doc and just give the Stelara good long trial and see how it goes. As for the Entyvio, I know that the protein that Entivio binds to is more heavily expressed in the...

Actually, starting in 2025 you can probably afford to switch the injections. A modification of the Medicare Part D rules that was included in Pres. Biden's massive trillion dollar infrastructure bill caps the Part D out of pocket expenses for Medicare recipients at $2000/year. The situation is...

I wonder about ronroush7. Back when I joined in 2015 he was a very active poster - always greeting new members and wishing everyone well, for years. He must have had thousands of posts. Then one day he abruptly stopped posting and never returned. I've often wondered whether he died or otherwise...

You might be confusing me with another forum member. My Stelara dosing is the standard 90 mg dose every 56 days and has not changed since I started on the drug about 7 years ago. Back when I started on the Stelara my symptoms noticeably improved after 2 or 3 weeks and achieved near-complete...

I'm sure that I very likely did. But the ulcerative proctitis patients in the study cited in the first post above also had their disease prior to their appendectomies. Some of them apparently benefitted from the procedure with reduced IBD symptoms. By contrast, my CD symptoms got much worse over...

I have Crohn's and not UC, but in my case appendectomy didn't help. I had an emergency appendectomy due to appendicitis with ruptured appendix. One year later I was diagnosed with Crohn's disease.

I suspect the sore legs are more exercise related rather than Crohn's related. That should clear up once he gets back in shape.

I'm doubtful of using response/nonresponse to biologics as a means of diagnosing Crohn's disease - for the simple reason that response to any given biologic can be quite variable for patients that have been successfully diagnosed by other means. You can see this occurring among Crohn's patients...

IMO, a calpro of 280 is not all that low. It's a definite positive result and it is more or less aligned with an inflamed area consisting of some aphthous ulcers confined to the terminal ileum (as opposed to big, flaming widespread ulcers). I don't know the UK National Health rules very well...

Have you tried getting a second opinion? Your case is much like mine was except in my case calprotectin was not measured and I suffered a bout of severe anemia. But I was undiagnosed until the capsule camera endoscopy showed a few aphthous lesions in the terminal ileum. That was the key finding...

In battling my Crohn's-related severe anemia I took a lot of those pills. Unfortunately, the steps that increase the absorption of the iron mostly tend to also increase the risk of stomach upset. For example, coated "enteric" pills delay the release of the iron until the pill is well...

Both fecal calprotectin (FCP) and especially C-reactive protein (CRP) are imperfect markers of inflammation, meaning that they miss some. My CRP has never been elevated no matter how inflamed my gut was. That test just doesn't work in my case. It's also worth noting that FCP and CRP are...

The linked article is apparently not warning about the dangers of dishwashers used in the home, which usually employ a clear water rinse cycle to remove the detergent. It is warning about the large commercial dishwashers used in restaurants and institutional settings that instead use a chemical...

My case was similar in some ways. Like you I had occasional diarrhea and a few instances of bloody diarrhea. I also has occasional unexplained fevers that each lasted a day. But my main symptoms were anemia and right lower quadrant abdominal pain. X-rays showed bowel wall thickening in the...

Given that the FDA is already comfortable with the IL-23 approach, and the drug is already approved for UC, and this is a very positive key Phase III study, assuming the Lilly doesn't drag it feet getting the application filed, I expect it to be approved sometime in 2025 - probably in the first...

Interesting. Although in my own trial of n=1, having received massive doses of penicillin at ages 4 and 5 to treat suspected rheumatic fever, did not prevent my developing Crohn's disease in middle age.

Omvoh, another IL-23 inhibitor, is already FDA approved for UC and is now reporting good results for Crohn's and performed better than Stelara. Quote from the link: "A greater number of patients that achieved histologic response were observed with mirikizumab at Week 52 in the overall...

One thing you will soon see from reading this forum is that no two Crohn's cases are exactly the same. IMO, there is no one definitive disease that defines Crohn's. Instead, Crohn's exists as a spectrum of similar, overlapping conditions that share many (but not all) features in common that may...

The good news is that these reports indicate that you have solid levels of Stelara in your blood and no detectable levels of anti-drug antibodies that could neutralize the beneficial effects of the drug. The bad news is that you have not achieved disease remission with Stelara and still require...