I have been on 50mg 6MP for about 6 weeks. On Saturday I was due to increase to 75mg by splitting a tablet but I forgot I was meant to split it and took two 50mg tablets so I had 100mg on Saturday night. Yesterday was horrendous! I had no energy, painful joints, painful muscles, no appetite and I spent the day in bed. Last night I took 50mg again and today I feel back to normal. My consultant wants me to go up to 100mg in a month and now I am pretty wary about it! Is spending time on 75mg likely to make me less prone to side effects? My bloods are still being done every three weeks at the moment and are improving but not within 'normal' ranges for CRP and platelets yet.