6mp dosage

[kh216]

Two months ago my 6mp dosage was increased from 75 mg to 100 mg and I am trying to wean off of Entocort. I started with three Entocort pills and then went down to two but now I'm experiencing problems being on just one Entocort pill. Today I called my GI doctor's partner and he told he to go back to taking 3 Entocort pills for the time being.

My question is: How long does it take to find out if increasing the 6mp dosage will help or not? When I first started taking 6mp, it took a good 5 months before the 6mp helped without Prednisone. However, I still needed to take Entocort along with the 75 mg dosage of 6mp.

 

[David]

Hi kh,

The answer is the dreaded, "Everyone is different". Now, there are some tests they could conduct to see if your metabolite levels are in the therapeutic range or not. I would suggest reading up on 6-TGN and 6-MMP and asking your doctor if testing those levels is possible if they haven't already. Because if your 6-TGN is too low, the 6-MP might never work. If they're in the therapeutic range, then chances are you're going to be feeling a difference soon.

 

[Jennifer]

I'm in the same boat where I haven't noticed a difference in the 6MP increase (I also went from 75mg to 100mg almost 3 months ago, I'm also on Entocort 9mg). My GI wanted me to try out those two doses for 3 months and see if it did anything. He said that if it doesn't we may have to try Humira. Hopefully it works for you soon. I know my symptoms aren't that bad but if yours are I understand how frustrating it would be. Keep us posted on how you're doing.

 

[kh216]

Thank you, Crabby. I called my doctor. It has only been two months on the new dosage so I will give it more time. I have a scheduled visit with my GI doctor next Thursday. I went to a GI doctor at University of Pennsylvania back in April and she said if this does not work, I should take a metabolite test to see if I could tolerate a 125 mg dosage. However, I don't know if my insurance will cover the metabolite test.

 

[Jennifer]

No harm in trying. Hopefully you wont wind up at square one with the whole, "what do we do now?"