You might need to try Humira or Remicade. Have you contacted your GI?
Yes, going for a biologic is definitely the most prominent choice.
Just to add to this, the other things you might consider are
a. what dosage of 6mp (mercaptopurine) are you on in mg/kg or mg/lbs? If the dosage is too low, it might just be that 6mp is ineffective. Also, how long have you taken it and are you consist in taking it (compliance as in daily, splitting the dosage to 2 times per day)?
b. how much asacol are you taking per day? Are you taking them orally or per enema?
As people have said above, other things to try is to adjust your diet. If you want a more radical approach on diet, you could go for EEN (exclusive enteral nutrition - basically you just go for drinkable supplements/formula for a few weeks) or do that partially. There are various other diet suggestions that have had success for acute flare-ups.
Lastly, there are of course a few other things as well, as medical marijuana that can help, or switching from 6mp to a different immunosuppressive (methotrexate - MTX) or even combination therapy, that is MTX and a biologic drug.
Having said all that, it is always a good idea to read up on the various threads that others have started on this forum. Reading many threads with the various approaches people have taken really gives you a great overview of what is out there and what has worked for others.
