Chlamydia pneumoniae

[Igor_Passau]

Chlamydia pneumoniae Infection of the
Central Nervous System in Multiple Sclerosis

Our identification of Chlamydia pneumoniae in the cerebrospinal fluid (CSF) of a patient with multiple sclerosis (MS) led us to examine the incidence of this organism in the CSF from 17 patients with relapsing–remitting MS, 20 patients with progressive MS, and 27 patients with other neurological diseases (OND). CSF samples were examined for C pneu- moniae by culture, polymerase chain reaction assays, and CSF immunoglobulin (Ig) reactivity with C pneumoniae ele- mentary body antigens. C pneumoniae was isolated from CSF in 64% of MS patients versus 11% of OND controls. Polymerase chain reaction assays demonstrated the presence of C pneumoniae MOMP gene in the CSF of 97% of MS patients versus 18% of OND controls. Finally, 86% of MS patients had increased CSF antibodies to C pneumoniae elementary body antigens as shown by enzyme-linked immunosorbent assay absorbance values that were 3 SD greater than those seen in OND controls. The specificity of this antibody response was confirmed by western blot assays of the CSF, using elementary body antigens. Moreover, CSF isoelectric focusing followed by western blot assays revealed cat- ionic antibodies against C pneumoniae. Infection of the central nervous system with C pneumoniae is a frequent oc- currence in MS patients. Although the organism could represent the pathogenetic agent of MS, it may simply represent a secondary infection of damaged central nervous system tissue. A therapeutic trial directed at eliminating C pneumoniae from the central nervous system may provide additional information on its role in MS.
http://www.cpnhelp.org/pdfs/Cp-MSAssoc.pdf

 

[Igor_Passau]

Chlamydia pneumoniae and the risk for exacerbation in multiple sclerosis patients.

http://www.ncbi.nlm.nih.gov/pubmed/14681894

 

[Igor_Passau]

Infection with Chlamydia pneumoniae and Risk of Multiple Sclerosis

http://journals.lww.com/epidem/Abst..._with_Chlamydia_pneumoniae_and_Risk_of.6.aspx

Chlamydia pneumoniae and Multiple Sclerosis: The Latest Etiologic Candidate

http://journals.lww.com/epidem/Full...pneumoniae_and_Multiple_Sclerosis__The.2.aspx

 

[Igor_Passau]

Intrathecal production of Chlamydia pneumoniae-specific high-affinity antibodies is significantly associated to a subset of multiple sclerosis patients with progressive forms

http://www.jns-journal.com/article/S0022-510X(03)00287-9/abstract

 

[Igor_Passau]

Qualitative and Quantitative Detection of Chlamydophila pneumoniae DNA in Cerebrospinal Fluid from Multiple Sclerosis Patients and Controls
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664471/

Chlamydophila pneumoniae DNA and mRNA transcript levels in peripheral blood mononuclear cells and cerebrospinal fluid of patients with multiple sclerosis

http://www.sciencedirect.com/science/article/pii/S0168010208001491

 

[Igor_Passau]

Easing mitochondrial stress in chronic Chlamydia pneumoniae infections: the use of dietary supplements

http://www.davidwheldon.co.uk/supplement_rationale.html

 

[Igor_Passau]

Patient Stories
http://www.cpnhelp.org/patient_stories

IBD

http://www.cpnhelp.org/node/4743

 

[Igor_Passau]

Chlamydia has been associated with autoimmune diseases, but a link between chlamydial infection and the aetiopathogenesis of inflammatory bowel disease (IBD) remains controversial. In this study we assessed the relationship between chlamydial infection and IBD, as evidenced by serological measurement and DNA analysis of mucosal biopsy specimens
http://www.ncbi.nlm.nih.gov/pubmed/16825908

Inflammatory bowel disease, a collective term for ulcerative colitis and Crohn's disease, is a chronic, immune-mediated disease of the gastrointestinal tract that develops in genetically susceptible individuals. The role of infection in the development of inflammatory bowel disease is underscored by various clinical observations, such as the delayed age of onset, suggesting that childhood exposure to pathogens is essential, and the clinical improvement that follows decreasing bacterial intestinal load. Over the years, many a pathogen has been linked to the development and exacerbation of inflammatory bowel disease, notably; Mycobacterium paratuberculosis, Escherichia coli, Listeria monocytogenes and Chlamydia as well as viruses such as measles, mumps, rubella, Epstein-Barr virus and cytomegalovirus. Presently, leading theories of disease pathogenesis suggest loss of immune tolerance to normal commensal bacteria coupled with excessive exposure to bacterial antigenic products. This review describes the most commonly implicated pathogens in the causation of IBD and presents the evidence supporting their pathogenic role as
well as data that offset their importance.

http://www.ima.org.il/imaj/ar09sep-10.pdf