Contribution of genetic and environmental factors in the pathogenesis of Crohn's disease in a large family with multiple cases.

[kiny]

 

[kiny]

A friend showed me this study, then I wondered if I should post it since it's outdated because it's from 2007, but the study is so special that I felt I should.

This is very interesting to me since people from the middle east have immigrated to Europe recently. In the Middle East crohn's disease is much rarer than in the Europe.

However, quite a number of studies have shown now that those people who immigrate to Europe with low indices often have more crohn's disease in their communities than the locals after immigration. This is specifically true for moroccans who move to Germany and Belgium.

This is a study about one moroccan who moved to Belgium, he did not have crohn's disease nor did any of his children, once in Europe he developed crohn's disease and so did 4 of his 8 children.

Shockingly, they didn't carry NOD2 mutations or other mutation seen in crohn's disease.

Why did this dad and 4 out of 8 children develop crohn's disease without carrying any genetic mutations specific for crohn's disease.

 

[Clash]

Why didn't they list NOD2 in the study or does NOD1 cover it?

Thanks kiny, this is interesting.

 

[kiny]

it's sometimes referred to as CARD15 like above, or IBD1

 

[Clash]

I thought that my be the case and from your other posted articles and research, I have ascertained that in the West a certain segment of CD population have a mutated NOD2 but more people with the mutated NOD2 gene don't have CD?

 

[kiny]

That's right, most people with mutations in NOD2 don't have crohn's disease.

 

[kiny]

Here is a similar story if it really interests you Clash. It's really interesting to read and I have most bookmarked.

I am also interested in studies that deal with identical twins, is the chance higher or lower if they are seperated at birth? Does it matter if they live under the same roof or not?

 

[kiny]

When people say bad diet or hygiene hypothesis, this evidence is impossible to justify with this. You have 7 out of 11 children who got crohn's disease, some within 13 months of each other. This is not "bad diet" or "lifestyle" or "westernisation". There is either an agent in the environment causing this or the disease is infectious.

There are studies from Liege that show similar events.

In 1854 there was a pump in England, on Broad Street, 500 people died around that street. The reason was the pump giving them cholera.

It's known clustering happens in crohn's disease, but family clustering without genetic markers happens too, impossible to explain through diet or westernisation.

 

[kiny]

 

[kiny]

family clustering, not evenly distributed like you would expect if the reason was genetic susceptibility, but non-random distribution, which is only possible through environmental events

specific agents in the environment that are local to the clustered group, not "westernised diet" or "hygiene theory' since that's a national event, clustering is a localised event on a small scale

 

[Livilou]

Thank You for posting this kiny, so very interesting considering 2 out of my 3 children, and my Mom all have CD with similar disease patterns. Kim

 

[rollinstone]

Thanks for your efforts posting this research kiny I always love reading it