kiny
Well-known member
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- Apr 28, 2011
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http://jid.oxfordjournals.org/content/206/11/1763.long
Crohn's disease susceptibility genes are associated with leprosy in the Vietnamese population.
Grant AV, Alter A, Huong NT, Orlova M, Van Thuc N, Ba NN, Thai VH, Abel L, Schurr E, Alcais A.
Laboratoire de Génétique des Maladies Infectieuses, Paris, France.
A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and NOD2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn's disease and leprosy.
Crohn's disease susceptibility genes are associated with leprosy in the Vietnamese population.
Grant AV, Alter A, Huong NT, Orlova M, Van Thuc N, Ba NN, Thai VH, Abel L, Schurr E, Alcais A.
Laboratoire de Génétique des Maladies Infectieuses, Paris, France.
A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and NOD2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn's disease and leprosy.
