Curcumin reduces the antimicrobial activity of ciprofloxacin against Salmonella Typhimurium and Salmonella Typhi.

[kiny]

Not sure why I link this, it's not directly related to IBD, but turmeric is popular amongst IBD so is cipro use, maybe it's interesting for people who use either to know there is a cross-reaction.

http://www.ncbi.nlm.nih.gov/pubmed/23070736

Curcumin reduces the antimicrobial activity of ciprofloxacin against Salmonella Typhimurium and Salmonella Typhi.

2012 Oct 15

Marathe SA, Kumar R, Ajitkumar P, Nagaraja V, Chakravortty D.

Centre for Infectious Disease Research and Biosafety, India


OBJECTIVES:

Typhoidal and non-typhoidal infection by Salmonella is a serious threat to human health. Ciprofloxacin is the last drug of choice to clear the infection. Ciprofloxacin, a gyrase inhibitor, kills bacteria by inducing chromosome fragmentation, SOS response and reactive oxygen species (ROS) in the bacterial cell. Curcumin, an active ingredient from turmeric, is a major dietary molecule among Asians and possesses medicinal properties. Our research aimed at investigating whether curcumin modulates the action of ciprofloxacin.

METHOD:

We investigated the role of curcumin in interfering with the antibacterial action of ciprofloxacin in vitro and in vivo. RT-PCR, DNA fragmentation and confocal microscopy were used to investigate the modulation of ciprofloxacin-induced SOS response, DNA damage and subsequent filamentation by curcumin. Chemiluminescence and nitroblue tetrazolium reduction assays were performed to assess the interference of curcumin with ciprofloxacin-induced ROS. DNA binding and cleavage assays were done to understand the rescue of ciprofloxacin-mediated gyrase inhibition by curcumin.

RESULTS:

Curcumin interferes with the action of ciprofloxacin thereby increasing the proliferation of Salmonella Typhi and Salmonella Typhimurium in macrophages. In a murine model of typhoid fever, mice fed with curcumin had an increased bacterial burden in the reticuloendothelial system and succumbed to death faster. This was brought about by the inhibition of ciprofloxacin-mediated downstream signalling by curcumin.

CONCLUSIONS:

The antioxidant property of curcumin is crucial in protecting Salmonella against the oxidative burst induced by ciprofloxacin or interferon γ (IFNγ), a pro-inflammatory cytokine. However, curcumin is unable to rescue ciprofloxacin-induced gyrase inhibition. Curcumin's ability to hinder the bactericidal action of ciprofloxacin and IFNγ might significantly augment Salmonella pathogenesis.

 

[D Bergy]

It is likely that any oxidizing treatment would be hampered by curcumin or the many other antioxidants. This is fairly well understood in the alternative treatment realm.

Whenever an oxidizing treatment, such as ozone is used all antioxidants should be discontinued. Vitamin C is also an antioxidant.

I was not aware that cipro was also affected by antioxidants.

Thank you for the info.

Dan

 

[Shake-N-Jake]

Kiny, I use turmeric spice everyday, I do not take cipro or anything else besides Remicade! Is the study suggesting not to take turmeric when using antibiotics or in general?

 

[kiny]

Hi, idk, it's not really suggesting anything since they're not doctors, nor is it directly related to crohn. What it is saying is that turmeric inhibits the effectiveness of ciprofloxacin against salmonella, so any crohn's disease patients on cirprofloxacin might want to take that into account and might want to be careful about taking turmeric. It says nothing about taking turmeric when you're not on antibiotics, I have no idea if it is helpful for crohn or not.

I don't want to ever tell someone what to take or what not to take, I just wanted to put the info out there for others to see, so they know that taking both together might cause an unwanted effect.