Donk4263 - I also get the flu like symptoms, but they usually start about 2-6 hrs after my infusion and last about 12-24 hrs. My husband was also on a drug similar for his MS which gave him the same symptoms and his dr told him to try Thera-Flu to help, which it did help. My next infusion is tomorrow, so I will let you know if it helps and might be something to keep in mind.