leaky gut precedes crohns. this is big and needs to be well known so that people can take measures to reverse/prevent
[URL unfurl="true"]https://crohnsandcolitis.ca/News-Events/News-Releases/GEM-Study-Links-Leaky-Gut-to-Crohn-s-disease[/URL]
GEM Study Links Leaky Gut to Crohn’s Disease
International project led by Crohn’s and Colitis Canada is getting us closer to preventing Crohn’s disease and ultimately, a cure
TORONTO, ON – August 20, 2020 – Crohn’s and Colitis Canada is pleased to announce that the world-renowned Genetic, Environmental, Microbial (GEM) Project has led to a significant finding.
The study found that healthy first-degree relatives of Crohn’s disease patients, who eventually developed Crohn’s disease themselves, had abnormal LacMan ratios when enrolled in the study. Gut barrier integrity was measured using Lactulose Mannitol Ratio or LacMan ratio. Lactulose is a large sugar that normally does not cross the gut barrier. Higher levels of lactulose in the urine is suggestive of a leaky gut.
This is the first report of pre-existing abnormal barrier function in a large study of healthy individuals followed over time for the development of Crohn’s disease demonstrating that the LacMan ratio can predict disease.
