Histamine and crohn's

[my little penguin]

Mucosal Histamine Content and Histamine Secretion in Crohn’s Disease, Ulcerative Colitis and Allergic Enteropathy

Raithel M.a · Matek M.a · Baenkler H.W.a · Jorde W.b · Hahn E.G.a
a1. Department of Medicine, Institute of Clinical Immunology and Allergy of the University Erlangen-Nuremberg andbAsthma Clinic Mönchengladbach, Germany
Int Arch Allergy Immunol 1995;108:127–133 (DOI:10.1159/000237129)

Abstract
Histamine exhibits various biological effects in inflammatory and immunological reactions. To further define its potential role in allergic enteropathy and inflammatory bowel disease, both gut mucosal histamine levels and histamine release from endoscopic biopsy samples were measured. Tissue histamine content resulted from addition of the released amount of histamine and the remaining part of tissue histamine. The results demonstrate highly elevated mucosal histamine levels of the large intestine in allergic enteropathy. In inflammatory bowel disease histamine content and secretion were found to be significantly increased particularly in affected mucosa of Crohn’s disease and ulcerative colitis than in unaffected tissue or in healthy controls. These findings give strong evidence that mast cell mediators like histamine play a role in the pathogenesis of these diseases. Mucosal histamine is thus concluded to contribute to the immunoinflammatory reactions of the intestine found in these disease states and to reflect the degree of colonic inflammation in Crohn’s disease and ulcerative colitis.

from:

http://www.karger.com/Article/Abstract/237129

 

[positivemum]

I just happened upon this post as it had histamine in the title. Would the fact my son (14) has excessive mucus in his throat be linked to this? If so what can we do?

 

[IAmTheWalrus]

I asked about this before. I've had hayfever since I can remember, and I get it bad during the summer. Histamine forms in the gut, it has to play a part.

Who else has allergies?

 

[araceli]

Hmmmm. My son started having allergies for the first time this year. Don't know to what yet. We have an appointment in one week with the allergy Doc.

 

[723crossroads]

I too for the first time ever had them this year and developed a cough I never had. I had to take antihistimines to breathe many days this summer. The last three days haven't been as bad, but I was still wheezing last night. I especially here that at night. Anyone else wheeze?

 

[Stephyjane]

My daughter has had allergic rhinitis since about the age of 3 years.

 

[Mehita]

After having his worst flare ever, my son had allergies for the first time this year and needed Zyrtec daily. No idea what he's allergic too yet. I think there is a connection, though someone suggested that it could be due to a hormonal changes since he just started puberty this year as well.

 

[Farmwife]

I never knew Grace had allergies until we started testing her.

It's within the last year that all this allergy stuff has hit her.

 

[positivemum]

Mehita - we are in puberty too. He used to have sneezing and itchy eyes hayfever but that has not been obvious this year. Just this mucus in his throat. I did get told that the consistency of mucus becomes thicker in puberty and young children's is thin and watery

 

[ChampsMom]

My son takes Citirizine daily for his allergies (though he says he doesn't think it helps)... he has more snot than anyone I have ever met!

723Crossroads - he has had some wheezing problems this year (we were referred to a cardiologist as he had some chest pains with it). They concluded that it was exercise induced as it only happened when he was doing suicides in ice hockey or sprints on the field.

 

[Sascot]

My son started hayfever during spring/summer with itchy eyes/snotty nose and wheezing at around 5 or 6 years old - funnily enough around the same time tummy pains started. The allergies seem better the last couple years though

 

[Clash]

C has always dealt with allergies, they had sort of slowed down during his middle school years but we recently had to change meds and add meds...fall is awful for him.

 

[DustyKat]

Matt has seasonal allergies...snuffly and itchy eyes...depending on the weather. Now if we could just have the perfect weather combination every year! :lol: Too dry (this year) hayfever heaven, too wet also means hayfever heaven. Thank god for Zyrtec and eye drops!

Dusty.

 

[David]

I'm curious how many of you list the foods on this page as a trigger: http://www.allergyuk.org/common-food-intolerances/histamine-intolerance

 

[Clash]

The first part of that list reads like C's favorite menu items although of course the beer/liquor, he wouldn't be telling me about that at 16.

Although I'm not sure he has tried everything on the second part of the list, of the ones I know he has eaten its only tomatoes he avoids and he has never cared for them.

Edit: He doesn't drink cola but not due to CD.

 

[ChampsMom]

My son does a lot of those foods.

He doesn't do dairy product (unless lactose free), a lot of raw veggies (though he'll do an occasional salad), and no seeds of any kind (including those in/on fruit), very little fruit (except bananas he eats daily in a smoothie).

 

[Mehita]

The only thing on that list that DS eats much of is cheese and bananas.

 

[Brian'sMom]

Can allergies cause the SED and CRP to elevate? And can onset of puberty as well?

 

[my little penguin]

Allergies do not cause sed rate or crp to increase .
Tryptase can increase after an anaphylaxis but that is

 

[Patricia56]

Interesting - sounds like a possible new path for therapeutic interventions.

 

[araceli]

I found out my son is allergic to 19 things out of the 32 he was tested today. He will be having 2 shots every week for the next 5 months. Next step is to do the food allergy test.

 

[Patricia56]

At the time, this was about 6 years ago, my son's allergist stopped my son's shots when we got the CD diagnosis.

The allergist said the shots are intended to activate the immune system (mildly) and he felt it was unwise to do anything that might increase inflammation or immune response given the CD diagnosis.

Obviously your allergist doesn't have this concern. I wonder if there's some new research that clarifies this possible concern.

MLP?? Our research guru? What do you think?

 

[araceli]

I talked to the Allergist about it, He said it will not be a problem. I will ask the GI today. Thanks a lot for the information I will research and find out more before we do the first shots.

 

[my little penguin]

Random food allergy testing is not recommended without h a known reaction
At least 50% or more of the test results are false positives

info on food allergy testing

http://www.newenglandsocietyofallergy.org/Meeting PDFs/Young.pdf

Interpreting positive food skin test results is more problematic. Positive tests indicate that IgE is present but do not, without confirmation from other sources, prove that a reaction will occur when you eat the food. In other words, the test can show a positive result or a false positive (a skin reaction even though you don't react to the food when you eat it).

False positives occur in the following scenarios:

You have a small amount of IgE antibody to a food but are not be truly allergic to that food. You can eat the food and experience absolutely no reaction to it.
Some proteins in foods are cross-reactive with similar proteins in other foods or even environmental allergens like pollens. This cross reactivity can lead, for example, to a falsely positive skin test for soy in a person with peanut allergy, or a positive test to wheat in a person with grass pollen allergy.
Some studies show that the larger the skin test (the bigger the bump on your skin at the site of the test), the more likely a true allergy is at work, although this has not proven true in other studies.

from:

http://drrobertwood.com/beware-false-positives.shtml

 

[my little penguin]

DS has had allergy shots for the past 5 years since age 4.
WE expressed a concern to the allergist.
His allergies are severe and meds will not keep them controlled.
There was no concern over allergy shots and CD from any of his specialists including his allergist.
CD is not IgE mediated. Pollen allergies are IgE mediated so different parts of the immune system so maybe that is why.

 

[LodgeLady]

I am newly diagnosed with Crohn's Disease (1 month ago). I have had allergies for years, but only after my first severe asthma attack, hospitalization, and months getting off of the prednisone for asthma, did I yield to allergy shots. I have taken them for 3 years now. Have felt great breathing and allergy wise. But now with this new diagnosis of Crohn's, I don't know what to think!

 

[my little penguin]

Please remember auto immune disorders are NOT the same as atopic disorders.
Your immune system is very complex which is why you can get an allergy shot even if you had a cold or other ailment but not if the same system ( ie asthma is flaring)
You can get a alkergy shot if your crohn's is flaring different parts of a very large system.
I know there was a picture chart somewhere on how the immune system works .

 

[LodgeLady]

Please remember auto immune disorders are NOT the same as atopic disorders.
Your immune system is very complex which is why you can get an allergy shot even if you had a cold or other ailment but not if the same system ( ie asthma is flaring)
You can get a alkergy shot if your crohn's is flaring different parts of a very large system.
I know there was a picture chart somewhere on how the immune system works .

This is good to read. I think really my immune system as a whole is just shot, so this new diagnosis does not really surprise me. In addition to the allergies, I am also allergic to bees (5 of them). No way I can even consider stopping the allergy shots (which also include the bees). Just now the Crohn's.....ugh