Humira, 6MP, and Prednisone?!

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Feb 5, 2016
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Hello!

Have any of you been on a biologic, either 6-MP or Azathioprine, and Prednisone at the same time? What was your experience?

I've been on Humira for about 5 months and was still experiencing symptoms and flaring about every other week, but only mild active inflammation showed on my CT. However, my GI decided to add on 6-MP because I was symptomatic. I was a little uneasy at the idea, but decided to trust my doctor. Well at the 2 week mark of the 6-MP and Humira combo, I developed erythema nodosum pretty badly on my legs and arms. My GI was concerned and put me on a fast 5 week taper of Prednisone to take care of it and to help while the 6-MP takes effect. She also asked if I'd had my Humira levels checked (I had, they're all normal).

I'm a little scared to be on so much medication, especially since I was considered mild to moderate when diagnosed. I've said I really don't mind dealing with symptoms here and there as long as I'm not in constant flare, but my doctors have been hell bent on remission.

I know these drugs have major benefits for helping with the disease and kicking that inflammation down. I'm just a little scared and would really love to know what everyone else has been through!
 
I have been on Cimzia which was good for a while but then wore off. I developed a reaction to Remicade after a while. I have been on Stelara but I am going to be switched to Humira. That is all for me personally. Everyone is different. I wonder if you need to be switched to another biologic. Maybe,you should ask your doctor about another biologic.
 
Hi I'm currently on cimzia, methotrexate and pred so far this has been the only way to keep me relatively healthy. I'm hoping I will be off the pred soon as I hate the side effects but it really helps in the short term. I'm continuing on 10mg of pred until my next Drs appointment in March and then hopefully I can come off them and just be down to the two medications. It can be scary taking all of this and reading the safety info that comes with them but I don't think I would cope without them.
I would see when you come off the pred if symptoms return then maybe you may need to try a different medication/combo but hopefully this will just give your body enough time to get the 6mp working.
 
Ds was on humira Mtx and pred more than once
It was what he needed at the time
Beware that 6-mp takes three months to become effective so not sure how a 5 week taper is going to help since 6-mp can't take over for 3 months

Are you in humira every week or every two weeks ?
 

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