I've only been on the Humira for 16 months but so far so good. Fistulas gone, pain and inflammation gone. Tired tho (extremely), but whether thats the Humira or the Crohn's I'm not sure. I have extra precautions(xray once a year) as I have tested positive for TB in my life before Crohns. I've only had one bout with bronchitis since I started which is fabulous as I would have had at least two maybe three episodes per year before. BUT everyone reacts differently to drugs and illness so you really would have to try it to see for yourself. If you do , I sincerely hope it is the one that does the trick,