Humira losing its effectiveness?

[snowhite_dahlia]

Hi all - I have been reading this forum for a while and finally decided to come forward with my own question.

I was diagnosed with moderate to severe Crohn's in 2005 and the only thing that could get me under control was Remicade. Unfortunately, after a few years, it lost it's effectiveness and I was transitioned over to Humira.

I've been on Humira for nearly four years with great results -- up until recently. It's like in the past few months it just STOPPED working. I've had horrible pain almost every day. Recently, I got bumped up to taking a 40mg dose every week and yet I still had a massive flare. 50mg of Prednisone is just barely keeping me in check.

I have a colonoscopy scheduled in a few days and I'm hoping to get some answers there but wanted to see if anyone has had this type of experience? Of the Humira quitting on you after a while? I'm wondering if maybe I could switch over to Cimzia - has anyone transitioned from Humira to Cimzia, and if so, how was it?

I had my Crohn's under control for so long and in the past few months it feels like it's just ruined my life.

 

[nogutsnoglory]

Sorry it's not working but it's not unusual. It works for some for only a few months and others for years.

 

[effdee]

Unfortunately, it's not that uncommon for the biologics to stop working after a while. I had about a year of efficacy on Remicade and Humira each, and then went to Cimzia which only helped for a few months. I improved with the first two startup doses, then fell off shortly after that. Hopefully, since you've had a couple years of success with Remicade and Humira, Cimzia will work for a while for you.

Aside from Prednisone and the biologics, what treatments have you tried?

 

[Smika]

It's not umcommon. Humira seemed to just quit working for me as well for the past 2 months. (I'm on 50mg of presnisone as well). Surgery is now my only option. Seen my surgeon on Jan 2nd and am having my second resection done on Jan 28th :voodoo: