kiny
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http://www.cell.com/AJHG/retrieve/pii/S0002929712005137
Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases
Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
December 2012
Hong Liu1, Astrid Irwanto, Hongqing Tian1, Xi'an Fu, Yongxiang Yu, Gongqi Yu,Huiqi Low, Tongsheng Chu Yi Li, Benqing Shi, Mingfei Chen, Yonghu Sun, Chunying Yuan, Nan Lu, Jiabao You, Fangfang Bao, Jinghui Li, Jian Liu, Huaxu Liu, Dianchang Liu, , Xiulu Yu, Lin Zhang, Qing Yang, Na Wang, Guiye Niu, Shanshan Ma, Yan Zhou, Chuan Wang, Shumin Chen, Xuejun Zhang, Jianjun Liu2, and Furen Zhang
Of eight leprosy susceptibility loci identified by genome-wide association studies, five have been implicated in Crohn disease, suggesting a common genetic fingerprint between leprosy and inflammatory bowel disease (IBD). Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese population and discovered two associations at rs2058660 on 2q12.1 (p = 4.57 × 10(-19); odds ratio [OR] = 1.30) and rs6871626 on 5q33.3 (p = 3.95 × 10(-18); OR = 0.75), implicating IL18RAP/IL18R1 and IL12B as susceptibility genes for leprosy. Our study reveals the important role of IL12/IL18-mediated transcriptional regulation of IFN-γ production in leprosy, and together with previous findings, it demonstrates the shared genetic susceptibility between infectious and inflammatory diseases.
Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases
Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
December 2012
Hong Liu1, Astrid Irwanto, Hongqing Tian1, Xi'an Fu, Yongxiang Yu, Gongqi Yu,Huiqi Low, Tongsheng Chu Yi Li, Benqing Shi, Mingfei Chen, Yonghu Sun, Chunying Yuan, Nan Lu, Jiabao You, Fangfang Bao, Jinghui Li, Jian Liu, Huaxu Liu, Dianchang Liu, , Xiulu Yu, Lin Zhang, Qing Yang, Na Wang, Guiye Niu, Shanshan Ma, Yan Zhou, Chuan Wang, Shumin Chen, Xuejun Zhang, Jianjun Liu2, and Furen Zhang
Of eight leprosy susceptibility loci identified by genome-wide association studies, five have been implicated in Crohn disease, suggesting a common genetic fingerprint between leprosy and inflammatory bowel disease (IBD). Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese population and discovered two associations at rs2058660 on 2q12.1 (p = 4.57 × 10(-19); odds ratio [OR] = 1.30) and rs6871626 on 5q33.3 (p = 3.95 × 10(-18); OR = 0.75), implicating IL18RAP/IL18R1 and IL12B as susceptibility genes for leprosy. Our study reveals the important role of IL12/IL18-mediated transcriptional regulation of IFN-γ production in leprosy, and together with previous findings, it demonstrates the shared genetic susceptibility between infectious and inflammatory diseases.
