Hi FireflyX,
I have a little bit of information on why they believe smoking is bad for Crohn's Disease patients.
- As Iamthewalrus mentioned, researchers believe the nicotine is probably one of the major causes of smoking-related problems in Crohn's.
- Also, it seems that a component of the tobacco itself stimulates the inflammatory response (glycoprotein in the tobacco causes this)
- Smoking increases Reactive Oxygen Species (ROS) which are very damaging to multiple components in cells. Many people take "anti-oxidant" supplements to reduce ROS levels and help protect cells against damage.
- Smoking also reduces the amount of antioxidants that the body can store.
- Women have a more pronounced effect of smoking and its exacerbation of Crohn's Disease
- Smokers have 2 fold increased relapse rate over nonsmokers and increased need for surgery, and increased risk for multiple surgeries.
- Smokers have more Crohn's related pain than nonsmokers in general.
- I found some info about heavy smokers (greater than 10 cigarettes per day) versus nonsmokers or persons that smoke less than 10 cigarettes per day. Researchers showed nonsmokers had inflammatory activity 37% of the time, smokers (less than 10 cigarettes per day) had inflammation 46% of the time, and heavy smokers had inflammation 48% of the time.
I found this article. Maybe it will be helpful?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180011/pdf/WJG-17-3567.pdf
Good Luck!