I thought it would be good to have a thread where links to empirical info on how and why MM works for Crohn's, colitis and IBD was put together in one place. If this works out maybe it could be made into a sticky. Here' a link to start it off:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931570/
This is from the British Journal of Pharmacology. Quote: In conclusion, treatment with THC, CBD and sulphasalazine reduced signs of damage, inflammation and functional disturbances in a rat model of Crohn's disease. THC was the most effective drug, because it significantly improved all parameters and importantly, unlike the reference drug sulphasalazine, it improved the function of cholinergic motoneurons. CBD on its own also displayed beneficial actions, such as improved spontaneous activity and contractility to carbachol, which extends previous findings (Malfait et al., 2000; Borrelli et al., 2009) and further suggests that this phytocannabinoid, which is devoid of psychoactive properties, could help alleviate symptoms in human IBD. Combined treatment with CBD and THC proved beneficial in TNBS-induced colitis in the rat, as it resulted in additive effects on some functional parameters and as CBD caused an ineffective dose of THC (5 mg·kg−1) to produce beneficial effects of the same magnitude as those produced by a higher dose of THC (10 mg·kg−1) in the absence of CBD. It is possible therefore that the benefit-to-risk ratio may well be greater when CBD and THC are co-administered to ameliorate colitis than when THC is administered alone. Further studies will be necessary to identify the mechanisms responsible for the observed effects. What I'm getting from this is that THC and CBD together work better than either one alone, and you can use less THC if used with CBD.If you have something to contribute, let's here from you! Thanks, Pete
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931570/
This is from the British Journal of Pharmacology. Quote: In conclusion, treatment with THC, CBD and sulphasalazine reduced signs of damage, inflammation and functional disturbances in a rat model of Crohn's disease. THC was the most effective drug, because it significantly improved all parameters and importantly, unlike the reference drug sulphasalazine, it improved the function of cholinergic motoneurons. CBD on its own also displayed beneficial actions, such as improved spontaneous activity and contractility to carbachol, which extends previous findings (Malfait et al., 2000; Borrelli et al., 2009) and further suggests that this phytocannabinoid, which is devoid of psychoactive properties, could help alleviate symptoms in human IBD. Combined treatment with CBD and THC proved beneficial in TNBS-induced colitis in the rat, as it resulted in additive effects on some functional parameters and as CBD caused an ineffective dose of THC (5 mg·kg−1) to produce beneficial effects of the same magnitude as those produced by a higher dose of THC (10 mg·kg−1) in the absence of CBD. It is possible therefore that the benefit-to-risk ratio may well be greater when CBD and THC are co-administered to ameliorate colitis than when THC is administered alone. Further studies will be necessary to identify the mechanisms responsible for the observed effects. What I'm getting from this is that THC and CBD together work better than either one alone, and you can use less THC if used with CBD.If you have something to contribute, let's here from you! Thanks, Pete
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