It's here! An article on using FMT for treating Crohn's

[ppk]

Promising results. Paging wildbill...

Fecal Microbial Transplant Effect on Clinical Outcomes and Fecal Microbiome in Active Crohn’s Disease
David L. Suskind, MD,* Mitchell J. Brittnacher, PhD,† Ghassan Wahbeh, MD,* Michele L. Shaffer, PhD,*
Hillary S. Hayden, PhD,† Xuan Qin, PhD,‡ Namita Singh, MD,§ Christopher J. Damman, MD,k Kyle R. Hager,† Heather Nielson,* and Samuel I. Miller, MD†,k,¶,**

Background: Crohn’s disease (CD) is a chronic idiopathic inflammatory intestinal disorder associated with fecal dysbiosis. Fecal microbial transplant (FMT) is a potential therapeutic option for individuals with CD based on the hypothesis that changing the fecal dysbiosis could promote less intestinal inflammation.

Methods: Nine patients, aged 12 to 19 years, with mild-to-moderate symptoms defined by Pediatric Crohn’s Disease Activity Index (PCDAI of 10–29) were enrolled into a prospective open-label study of FMT in CD (FDA IND 14942). Patients received FMT by nasogastric tube with follow-up evaluations at 2, 6, and 12 weeks. PCDAI, C-reactive protein, and fecal calprotectin were evaluated at each study visit.

Results: All reported adverse events were graded as mild except for 1 individual who reported moderate abdominal pain after FMT. All adverse events were self-limiting. Metagenomic evaluation of stool microbiome indicated evidence of FMT engraftment in 7 of 9 patients. The mean PCDAI score improved with patients having a baseline of 19.7 6 7.2, with improvement at 2 weeks to 6.4 6 6.6 and at 6 weeks to 8.6 6 4.9. Based on PCDAI, 7 of 9 patients were in remission at 2 weeks and 5 of 9 patients who did not receive additional medical therapy were in remission at 6 and 12 weeks. No or modest improvement was seen in patients who did not engraft or whose microbiome was most similar to their donor.

Conclusions: This is the first study to demonstrate that FMT for CD may be a possible therapeutic option for CD. Further prospective studies are required to fully assess the safety and efficacy of the FMT in patients with CD.

 

[Nosebag]

Hopefully there will be more studies that show promise with faecal transplantation. It makes me think of trying to do it myself at home but the thought of blending faeces is really disgusting and I know some people are doing this. Whilst I know Dr. Borody is doing this already in Australia I and many other people I'm sure don't have that kind of money. I suppose faeces enemas is no more disgusting then getting infusions of mouse or rat antibodies every six or eight weeks.

 

[wild_one353]

Thanks!! we discussed this already in the Fecal transplant thread. If you read the first post of the FMT thread i started, you will also see more studies using FMT for crohn's and the women who has been cured 12 years ago with FMT, according to DR. Borody at least.

 

[ppk]

Hopefully there will be more studies that show promise with faecal transplantation. It makes me think of trying to do it myself at home but the thought of blending faeces is really disgusting and I know some people are doing this. Whilst I know Dr. Borody is doing this already in Australia I and many other people I'm sure don't have that kind of money. I suppose faeces enemas is no more disgusting then getting infusions of mouse or rat antibodies every six or eight weeks.

It's gross, but isn't our disease much, much worse than tolerating something so temporary?

Thanks!! we discussed this already in the Fecal transplant thread. If you read the first post of the FMT thread i started, you will also see more studies using FMT for crohn's and the women who has been cured 12 years ago with FMT, according to DR. Borody at least.

Ah, gotcha Bill. Well to me, this is sufficient evidence to go ahead and give FMT a shot. I will be developing a protocol similar to the one used in this study, but also combining the best aspects of other protocols, and using either my father and/or a friend as a donor.

 

[Nosebag]

Definitely worth the money if it was a cure or a treatment instead of imuran,humira weekly and steroids.

 

[wild_one353]

It's gross, but isn't our disease much, much worse than tolerating something so temporary?



Ah, gotcha Bill. Well to me, this is sufficient evidence to go ahead and give FMT a shot. I will be developing a protocol similar to the one used in this study, but also combining the best aspects of other protocols, and using either my father and/or a friend as a donor.

gotta have the donor follow a strict diet to boost clostridia bacteria. A fiber supp like inulin would be an easy addition to their diet. The concentration of clostridia ranges from 1-15% of the bacterial composition of stool. Mushrooms contain a fiber that can boost clostridia very selectively. good luck. I was on board with FMT in 2012.