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http://www.ccfa.org/research/latestnews?msource=HQ0706DMENWS&tr=y&auid=2767746
Identification of 4 new genes associated with Crohn's disease (ATG16L1, PHOX2B, NCF4 and FAM92B). These genes further implicate abnormal host responses to bacteria and defective bacterial killing/processing as key risk factors for developing small intestinal (ileal) Crohn's disease
• Increasing evidence that normal intestinal epithelial cell responses to bacteria are essential in preventing inflammation and that defective responses can lead to chronic intestinal inflammation
• Identification and confirmation of new pathways of immune activation (interleukin 17, 23, 27) that provide new targets for therapy of Crohn's disease
Identification of 4 new genes associated with Crohn's disease (ATG16L1, PHOX2B, NCF4 and FAM92B). These genes further implicate abnormal host responses to bacteria and defective bacterial killing/processing as key risk factors for developing small intestinal (ileal) Crohn's disease
• Increasing evidence that normal intestinal epithelial cell responses to bacteria are essential in preventing inflammation and that defective responses can lead to chronic intestinal inflammation
• Identification and confirmation of new pathways of immune activation (interleukin 17, 23, 27) that provide new targets for therapy of Crohn's disease