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I appreciate the response. Morphine doesn't effect my mood or cognition. I never "feel" high or drunk even on 120 mg po in a 24 hr period. What I have found is that I can live an almost normal life at that dosage with diarrhea and pain at tolerable levels. Reduce it and my symptoms increase. So, yes, I feel nervous about not taking it. I'm sure I've developed a tolerance. But the amount of drug required has not increased. It dismays me that my doctor is willing to allow me greater discomfort in order to fix the amount of MSIR to his comfort level. I am to discuss the matter with my PCP today; I don't expect miracles. Just a little understanding would be nice.