Low grade inflammation

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Jun 13, 2013
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Studies over the last 10 years or so suggest there may be a continuum between IBS and IBD, with some IBS patients having "low grade inflammation".

I am a case where I've been diagnosed with IBS due to negative results for e.g. calprotectin and other conventional markers for inflammation, yet, because I experience numerous extra-intestinal symptoms, it suggests something more is going on.

Pain and motility medications for IBS don't treat any of these extra-intestinal symptoms. If there is "low grade inflammation", this may explain why.

Just wondered if anybody has any relevant experiences on this score. I know there are some trials being done with e.g. mesalamine for IBS (and some that have been done, with mixed success). But what I'd be interested in is personal experiences - e.g. a gastro that actually explored this avenue.
 
Hello, IBS Dog. Good username BTW... I have not been involved in any trials but I can tell you my own personal experience. My current GI, believes I am in remission from my crohns because my markers are all negative that he looks at. However, I am still having severe tummy pain after eating with diarrhea and occasional constipation. He claims I have IBS or what he calls it functional. My sed rate and CRP have never been extremely high to began with. My PLT ct is normally increased and now my ferritin stores are high which is an indirect measure of inflammation. I too experience EPS like joint pain and eye problems. He doesn't have answers for this nor my daily fevers. My X-rays don't show active crohns except erythema. I believe after reviewing many forums that crohns hides deep into our mucosa layers making it hard to see sometimes. This is one reason it is hard to diagnose.
 

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