MAP in Italy: commensal or emerging human pathogen?

[kiny]

don't like posting stuff from money-grabbing Elsevier, but it is about MAP so I'm making an exception~

single biopsy results in no detection

multiple biopsies result in 82.1% detection in crohn's disease patients, 40% in UC

 

[kiny]

Wonder if some are still willing to make the argument that MAP is simply there because of increased permeability, and not pathogentic. If it was not pathogentic the rates of MAP prevalence between controls and crohn's disease patients would be much closer, CD always has extremely high numbers of MAP and LF82 AIEC and some other AIEC and other strains that could be considered pathogentic, and should be considered pathogentic in the case of crohn's disease.

How many clues do people need to see that we are unable to control pathogens because of genetic predisposition of a weak immune system, NOD2, ATG16L1 and other genes.

It's right there in front of you, and still some countries say MAP isn't an issue.

 

[kiny]

MAP is no longer a commensal, it is a pathogen and it is directly contributing to crohn's disease inflammation

MAP is found in much higher amount in CD
MAP is detected in biopsies
MAP is detected in feces of CD
MAP is detected in blood by culture and PCR in CD
MAP shows immune response in CD
Ptb shows clinical features that look exactly like CD

government: "eeeeh maybe there is some truth to it, but before we are 100% sure we aren't going to do anything"

maybe?