Microbiota of De-Novo Pediatric IBD: Increased Faecalibacterium Prausnitzii and Reduced Bacterial Diversity in Crohn's But Not in Ulcerative

[mf15]

This seems to put a different perspective on IBD, no dsybiosis in early onset
child colitis,that have not had meds. Crohn's a different story.
WOW, might have to start back at square one,or or it is weak mucus due to perhaps proteolytic activity or something else. They pretty much say that current assumptions might not be right. Stunned and this is from 2012.

Old Mike

http://www.nature.com/ajg/journal/v107/n12/full/ajg2012335a.html



Later data on BISCUIT study. Have to look into this one.Parabacteroides distasonis

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595230/



here is another new onset study from Norway

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459595

 

[wild_one353]

i have seen this before, it is interesting.

ibd may emerge from a disruption in many diverse bacterial communities, not just f prausnitzii. what seems to be the nature of these organisms is that their presence as a whole, is more responsible for controlling inflammation, not that one single species does this entire job by themselves and we expect to find only one piece missing and replace that one piece, it may be a little more synergistic then that rather then reductionistic/linear. for example, the whip worm/helminth can also regulate inflammatory responses and induce remission in ibd. we may not break it down to one organism, it may be a combination of a few different ones that do the same job as a team. so perhaps that may be why we can find two patients with high f. praus and one with none/low and still both have crohns, its not solely dependant upon one organism.

 

[kiny]

You should be careful going off of one study, levels of F Prau were reduced in people with CD in many studies:


"The total levels of F. prausnitzii in faecal samples from CD patients at presentation were lower than those in the other groups both before and after the treatment"

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2962807/


In your link it's increased in pediatric patients.

"Increased Faecalibacterium Prausnitzii and Reduced Bacterial Diversity in Crohn's"


So you can't draw any conclusions out of it.

The main question regarding dysbiosis is...is dysbiosis just the consequence of inflammation or is dysbiosis in any way causative or important.