Finally calming down after getting my first welt with a Humira injection. I've been on it for a few months with no problems, but I got a welt a little bigger than a dime around the injection site this time. At first I freaked out and thought the needle hadn't gotten in far enough and all my medicine was sitting just under my skin. Called Aetna's after-hours nurse hotline and had a nurse tell me it's just a minor skin reaction, which is not terribly uncommon. I also realized had forgotten to ice the area first, so that might have made things worse. Anyways, phew! Anyone else out there freak out when you got a welt for the first time? I feel so silly now.