Some of these may have been posted already, but I'd thought that I'd re-post with some headlines that sounded promising... You can probably 'Google' the headlines, which should bring up the articles.
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Researchers make Crohn's disease breakthrough
Vancouver Sun (Mar 19, 2012) - “Sharkey and the research team with Calgary's Hotchkiss Brain Institute and the Snyder Institute for Chronic Diseases at the University of Calgary discovered that proteins called "pannexins" are involved in the death of the neurons. When drugs were used to block the pannexins, cell death in the gastrointestinal tract was prevented.”
Stronger Intestinal Barrier May Prevent Cancer in the Rest of the Body, New Study Suggests
ScienceDaily (Feb. 21, 2012) - “It appears that the hormone receptor guanylyl cyclase C (GC-C) -- a previously identified tumor suppressor that exists in the intestinal tract -- plays a key role in strengthening the body's intestinal barrier, which helps separate the gut world from the rest of the body, and possibly keeps cancer at bay. A new drug containing GC-C is now on the verge of hitting the market, but its intended prescribed purpose is to treat constipation.”
How Vitamin D Inhibits Inflammation
ScienceDaily (Feb. 23, 2012) - "This study goes beyond previous associations of vitamin D with various health outcomes. It outlines a clear chain of cellular events, from the binding of DNA, through a specific signaling pathway, to the reduction of proteins known to trigger inflammation," said lead author Elena Goleva, assistant professor of pediatrics at National Jewish Health. "Patients with chronic inflammatory diseases, such as asthma, arthritis and prostate cancer, who are vitamin D deficient, may benefit from vitamin D supplementation to get their serum vitamin D levels above 30 nanograms/milliliter."
Inflammatory Bowel Disease Less Common in Sunny States
HealthDay News (Jan. 12, 2012) - People who live in sunnier regions of the United States are less likely to develop inflammatory bowel disease, a new study says.
Inflammatory Bowel Disease Emerges as a Global Disease
ScienceDaily (Jan. 4, 2012) — "The incidence and prevalence of inflammatory bowel disease (IBD) are increasing with time and in different regions around the world, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. Researchers found that the highest prevalence of IBD worldwide was reported in Canada and Europe, whereas Asia had a lower prevalence of IBD. In developing nations, IBD was a rare occurrence; however, as these nations have become more industrialized, the incidence of IBD has increased. Gender differences were inconsistent, suggesting that the disease occurred equally among females and males."
New Synthetic Molecules Treat Autoimmune Disease in Mice
ScienceDaily (Dec. 25, 2011) — "A team of Weizmann Institute scientists has turned the tables on an autoimmune disease. In such diseases, including Crohn's and rheumatoid arthritis, the immune system mistakenly attacks the body's tissues. But the scientists managed to trick the immune systems of mice into targeting one of the body's players in autoimmune processes, an enzyme known as MMP9. The results of their research recently appeared in Nature Medicine."
$6.75 million awarded to Case Western Reserve to study IBD
(Public release date: 20-Dec-2011) - "NIDDK grant to School of Medicine examines role of innate immunity.
For years, scientists have focused their attention on the role of lymphocytes and the adaptive immune system in the cause of Crohn's disease...
Dr. Cominelli and a team of investigators in the Digestive Health Research Center, using a spontaneous mouse model of ileitis, a type of Crohn's disease, discovered that the intestinal innate immune system may play a primary and critical role in causing the disease. The body's innate immune system represents the first line of general defense against harmful agents and includes infection-fighting cells. In the ileitis model, they found a deficit of these cells and as a result, harmful agents weren't being eliminated from the body. Previously, the scientific medical community thought there was a specific component triggering a reaction within the body, much like production of an antibody in response to a particular virus but rather it is a deficit in the body's natural immune system."
Personalized Treatment for Crohn's Disease a Step Closer Following Gene Mapping
ScienceDaily (Dec. 8, 2011) — "Three new locations for Crohn's Disease genes have been uncovered by scientists at UCL using a novel gene mapping approach.
The complex genetic and environmental causes of Crohn's Disease (CD) have long been difficult to untangle. CD, a type of Inflammatory Bowel Disease that affects about 100 to 150 people per 100,000 in Europe, is characterised by inflammation in the gastrointestinal tract. Even though twin and family studies suggest a high heritability for CD of 50-60%, so far the locations of much of the genetic information implicated in this chronic disease have remained elusive."
Clinical Trial Success for Crohn's Disease Cell Therapy
ScienceDaily (Mar. 30, 2011) — "Speaking at the UK National Stem Cell Network annual science meeting on March 30, Professor Miguel Forte described research into a new cell therapy for chronic inflammatory conditions such as Crohn's disease. Patient's own blood cells are used to produce a type of cell -- Type 1 T regulatory lymphocyte -- that can reduce the extent of the disease."
29 Genome Regions Linked to Common Form of Inflammatory Bowel Disease
ScienceDaily (Feb. 6, 2011) — "An international team of researchers has made new links between 29 regions of the genome and ulcerative colitis -- a common form of inflammatory bowel disease (IBD). The new findings increase the total number of genome regions known to be associated with inflammatory bowel disease to 99."
<<>>
Researchers make Crohn's disease breakthrough
Vancouver Sun (Mar 19, 2012) - “Sharkey and the research team with Calgary's Hotchkiss Brain Institute and the Snyder Institute for Chronic Diseases at the University of Calgary discovered that proteins called "pannexins" are involved in the death of the neurons. When drugs were used to block the pannexins, cell death in the gastrointestinal tract was prevented.”
Stronger Intestinal Barrier May Prevent Cancer in the Rest of the Body, New Study Suggests
ScienceDaily (Feb. 21, 2012) - “It appears that the hormone receptor guanylyl cyclase C (GC-C) -- a previously identified tumor suppressor that exists in the intestinal tract -- plays a key role in strengthening the body's intestinal barrier, which helps separate the gut world from the rest of the body, and possibly keeps cancer at bay. A new drug containing GC-C is now on the verge of hitting the market, but its intended prescribed purpose is to treat constipation.”
How Vitamin D Inhibits Inflammation
ScienceDaily (Feb. 23, 2012) - "This study goes beyond previous associations of vitamin D with various health outcomes. It outlines a clear chain of cellular events, from the binding of DNA, through a specific signaling pathway, to the reduction of proteins known to trigger inflammation," said lead author Elena Goleva, assistant professor of pediatrics at National Jewish Health. "Patients with chronic inflammatory diseases, such as asthma, arthritis and prostate cancer, who are vitamin D deficient, may benefit from vitamin D supplementation to get their serum vitamin D levels above 30 nanograms/milliliter."
Inflammatory Bowel Disease Less Common in Sunny States
HealthDay News (Jan. 12, 2012) - People who live in sunnier regions of the United States are less likely to develop inflammatory bowel disease, a new study says.
Inflammatory Bowel Disease Emerges as a Global Disease
ScienceDaily (Jan. 4, 2012) — "The incidence and prevalence of inflammatory bowel disease (IBD) are increasing with time and in different regions around the world, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. Researchers found that the highest prevalence of IBD worldwide was reported in Canada and Europe, whereas Asia had a lower prevalence of IBD. In developing nations, IBD was a rare occurrence; however, as these nations have become more industrialized, the incidence of IBD has increased. Gender differences were inconsistent, suggesting that the disease occurred equally among females and males."
New Synthetic Molecules Treat Autoimmune Disease in Mice
ScienceDaily (Dec. 25, 2011) — "A team of Weizmann Institute scientists has turned the tables on an autoimmune disease. In such diseases, including Crohn's and rheumatoid arthritis, the immune system mistakenly attacks the body's tissues. But the scientists managed to trick the immune systems of mice into targeting one of the body's players in autoimmune processes, an enzyme known as MMP9. The results of their research recently appeared in Nature Medicine."
$6.75 million awarded to Case Western Reserve to study IBD
(Public release date: 20-Dec-2011) - "NIDDK grant to School of Medicine examines role of innate immunity.
For years, scientists have focused their attention on the role of lymphocytes and the adaptive immune system in the cause of Crohn's disease...
Dr. Cominelli and a team of investigators in the Digestive Health Research Center, using a spontaneous mouse model of ileitis, a type of Crohn's disease, discovered that the intestinal innate immune system may play a primary and critical role in causing the disease. The body's innate immune system represents the first line of general defense against harmful agents and includes infection-fighting cells. In the ileitis model, they found a deficit of these cells and as a result, harmful agents weren't being eliminated from the body. Previously, the scientific medical community thought there was a specific component triggering a reaction within the body, much like production of an antibody in response to a particular virus but rather it is a deficit in the body's natural immune system."
Personalized Treatment for Crohn's Disease a Step Closer Following Gene Mapping
ScienceDaily (Dec. 8, 2011) — "Three new locations for Crohn's Disease genes have been uncovered by scientists at UCL using a novel gene mapping approach.
The complex genetic and environmental causes of Crohn's Disease (CD) have long been difficult to untangle. CD, a type of Inflammatory Bowel Disease that affects about 100 to 150 people per 100,000 in Europe, is characterised by inflammation in the gastrointestinal tract. Even though twin and family studies suggest a high heritability for CD of 50-60%, so far the locations of much of the genetic information implicated in this chronic disease have remained elusive."
Clinical Trial Success for Crohn's Disease Cell Therapy
ScienceDaily (Mar. 30, 2011) — "Speaking at the UK National Stem Cell Network annual science meeting on March 30, Professor Miguel Forte described research into a new cell therapy for chronic inflammatory conditions such as Crohn's disease. Patient's own blood cells are used to produce a type of cell -- Type 1 T regulatory lymphocyte -- that can reduce the extent of the disease."
29 Genome Regions Linked to Common Form of Inflammatory Bowel Disease
ScienceDaily (Feb. 6, 2011) — "An international team of researchers has made new links between 29 regions of the genome and ulcerative colitis -- a common form of inflammatory bowel disease (IBD). The new findings increase the total number of genome regions known to be associated with inflammatory bowel disease to 99."
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