Niacin for Crohn's

[InstantCoffee]

http://www.usmedicine.com/oncology/could-niacin-megadoses-reduce-crohns-inflammation/

When the mice whose healthy colonic bacteria had been wiped out by antibiotics were given niacin, however, the vitamin helped steer immune cells in the colon into an anti-inflammatory mode, according to the researchers.

However

Niacin can cause upset stomach and diarrhea. However, all of these side effects tend to fade over time.

http://www.webmd.com/vitamins-and-supplements/lifestyle-guide-11/supplement-guide-niacin?page=3

 

[wild_one353]

I have confirmed that niacin does help supress some sypmtoms, I take 500mg nicotinic acid by natures way.

It activates the same receptor for butyrate. many b vitamin are made by gut bacteria, its not surprising that its doing some important stuff down there. one bad thing i read though is it can also suppress sirtuins which in turn may supress autophagy which is important for fighting intracellular bacteria. I recall having problems with 1000mg, so i would say 500mg is perfect.

Immunity. 2014 Jan 16;40(1):128-39. doi: 10.1016/j.immuni.2013.12.007. Epub 2014 Jan 9.
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.


Abstract

Commensal gut microflora and dietary fiber protect against colonic inflammation and colon cancer through unknown targets. Butyrate, a bacterial product from fermentation of dietary fiber in the colon, has been implicated in this process. GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation. Here we showed that Gpr109a signaling promoted anti-inflammatory properties in colonic macrophages and dendritic cells and enabled them to induce differentiation of Treg cells and IL-10-producing T cells. Moreover, Gpr109a was essential for butyrate-mediated induction of IL-18 in colonic epithelium. Consequently, Niacr1(-/-) mice were susceptible to development of colonic inflammation and colon cancer. Niacin, a pharmacological Gpr109a agonist, suppressed colitis and colon cancer in a Gpr109a-dependent manner. Thus, Gpr10a has an essential role in mediating the beneficial effects of gut microbiota and dietary fiber in colon.

 

[nogutsnoglory]

Interesting. I wonder if it was the flush niacin or non flush niacin used

 

[InstantCoffee]

Interesting. I wonder if it was the flush niacin or non flush niacin used

Shouldn't it be the same? Ultimately they result in the same thing, one just needs to be processed by the body and causes flushing.

 

[nogutsnoglory]

I read that they have different mechanisms of action but I'm not familiar enough. I know for detox after herxing for example they say very small dose of only the flush kind. So there is some difference.