Probiotic therapy

[my little penguin]

Probiotic therapy protects the epithelial barrier in acute colitis by preventing 1) decreased tight junction protein expression and 2) increased apoptotic ratio

Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis



From:

http://m.ajpgi.physiology.org/content/296/5/G1140.short

 

[Hope345]

Thank you for the link. I do believe the probiotics can help. There are many IBDers who use them with great success.

I am ordering milk kefir grains to make our own, which will be loaded with probiotics. I have been giving our daughter acidophillus which she has responded well too, but I have heard it is best to balance out the probiotics and change them up every once in a while. Our GI and many others have suggested only giving her a couple tablespoons a day to start with of the milk kefir when it is ready.

 

[CarolinAlaska]

Thank you for the link. I do believe the probiotics can help. There are many IBDers who use them with great success.

I am ordering milk kefir grains to make our own, which will be loaded with probiotics. I have been giving our daughter acidophillus which she has responded well too, but I have heard it is best balance out the probiotics. Our GI and many others have suggested only giving her a couple tablespoons a day to start with of the milk kefir when it is ready.

We do water kefir and milk kefir. They make a noticeable difference with Jaedyn's gassiness.

 

[kiny]

Thanks. I try not to put too much faith in these studies. These mice do not have crohn's disease, they do not have UC. They administer dextran sodium sulfate to the mice, which causes inflammation. So you're using a murine model that is very very different from crohn's disease.

Another thing is that DSS results in inflammation of the colon near the rectum, compared to enteritis like in CD.

The indigenous bacterial load is much higher in the colon, any probiotics are going to be far more beneficial for the colon than small intestine.

Nothing against the study, but I learned to put murine models with DSS induced inflammation into perspective, they are ar far away from a CD model.

 

[my little penguin]

Kiny-Actually that helps alot
Some of the issues my son is having is inflammation in his rectum to the point of rectal prolapse
Which is why we are trying the probiotics in addition to his others traditional crohn's meds .

 

[kiny]

Ah ok, sorry to hear, I hope the probiotics help him a bit.

 

[Dexky]

Nothing against the study, but I learned to put murine models with DSS induced inflammation into perspective, they are ar far away from a CD model.

Where? Where did you learn that?

 

[CrohnsKidMom]

MLP, I hope the probiotics helps. I did some inquiring at a few pharmacies about the VSL#3, but it doesn't seem to be available in Canada. So, I thought maybe some run-of-the-mill probiotics would be beneficial for my son. I checked out a couple brands, but they all include a warning that it should not be taken by someone with a suppressed immune system. So, I'm confused. Is the VSL something safer for those with Crohn's?

 

[my little penguin]

http://www.vsl3.ca

how to order it in canada

It has a 1 800 number

most pharmacy's do not carry it you have them order it special at least in the US.

The version DS is on is by prescription only.
The one for the canada link shows the lower non prescription version but still way higher than over the counter stuff.

hope that helps

 

[Twiggy930]

My son is taking TuZen and it seems to be helping. It is shelf stable so I just put it in his pill organizer each week, we kept forgetting the one that needed to be refrigerated.

 

[Hope345]

I go pick up the milk kefir grains tomorrow. I think they may be one of the best ways to get probiotics/organisms.

Carol: I might have a few questions for you as we get started tomorrow.