Prodrugs

[Astra]

Something has only just occured to me!
I thought that my fellow Crohnies were spelling Prednisolone wrong, and calling it Prednisone.
Apparantly, Prednisone is a prodrug, a substance administered in an inactive form.
Prednisone is converted by the liver into Prednisolone which is the active drug.
I'm just wondering, is this why some of us have horrific side effects with this drug, the Prednisone one?
I was on Prednisolone, and the side effects were minimal. I was happy on it, not moody or depressed.

I didn't know this, I didn't know there was a difference!

 

[Rebecca85]

*facepalm* maybe prednisolone has less side effects than prednisone because there's no by-products or something. I was on prednisolone but a relatively low dose (30mg) and I was moody, but not like some on herw get. Didn't really have trouble sleeping either. It could just be a coincidence though, maybe you're just not susceptible to the side effects!

 

[Astra]

Yeah Rebecca, that's what I'm wondering, does something happen during the morphing process? Is Prednisolone a lesser of two evils in the purer form?
I did get the insomnia and the moonface, but felt euphoric on it!
Maybe I'm just a weirdo?
Hope your resting Rebecca? Making the most of the school hols?
I am!
xxx

 

[mizgarnet]

Prednisone made me a WITCH. I cried, I screamed, I yelled, I whimpered. My anxiety levels were off the charts high on the nasty drug. The taper off created flaring. I will definitely ask about the prednisolone if I ever need steroids again. Thanks Joan for posting this.

Wendy

 

[Rebecca85]

Oh yes lovely holidays. Spent the first two days cleaning, (I only have a 2-up 2-down but it takes a long time with all the breaks!), the rest of the time I've been alternating between sleeping, eating and playing computer games.