Reduction of disulphide bonds unmasks potent antimicrobial activity of human b-defens

Crohn's Disease Forum

Help Support Crohn's Disease Forum:

kiny

Well-known member
Joined
Apr 28, 2011
Messages
3,465
http://saturn.med.nyu.edu/research/mp/littmanlab/Immunology_Journal_Club/Papers_files/Schroeder.pdf


Some notes if needed

*human b-defensin 1 (or hßD1) is a protein that acts as an antibiotic, our body makes it, it's one of the most powerful in our body

*people with crohn's and UC show they have less of these in their body (also linked to periodontitis, caries and candidiasis)

*it acts against lactic acid

*another protein, called thioredoxine, activates hßD1

*before this they didn't know what thioredoxine was, nor did they know why hßD1 didn't seem that active, it's because the thioredoxine didn't activate hßD1
 
Last edited:
Back
Top