DaveNotRoach, I've also been looking into that too. I had resisted meds for over a year, but recently decided to start Remicade after getting a repeat MRE showing expanded inflammation. If you dig around on the threads in the Remicade section of the forum, you'll definitely find a sprinkling of people who have been on Remi for a while and a bunch who had very quick responses, especially in situations with fistulizing Crohn's. There are certainly a few stories around about people developing resistance to Remi, but a few people have written about being on it for 8+ years, such as one here:
http://www.crohnsforum.com/showthread.php?t=65074
Good luck with things.